RECRUITING

Dietary Sodium, Oxidative Stress, and Pulsatile Hemodynamics

Conditions

Sodium Excess endothelium oxidative stress physical activity ventricular-vascular coupling pulsatile load

Quick Navigation

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

High sodium diets impair vascular function, which may influence the work of the heart. This investigation is designed to determine if this change in vascular function results in a greater workload in the heart and if people who regularly exercise are protected from these effects.

Official Title

The Role of Oxidative Stress and Endothelial Dysfunction in High Sodium-Induced Changes in Pulsatile Hemodynamics

Quick Facts

Study Start:2020-01-01

Study Completion:2024-12-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT04233957

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:21 Years to 45 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT

Inclusion Criteria	Exclusion Criteria
* Healthy individuals (age 21-45) who are either sedentary (1 or less days of exercise per week during past year) or habitually active (4 or more days of aerobic exercise per week for a minimum of 1 year)	* Body mass index \<18 or \>35 * Systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 * Blood donation within past 8 weeks, * Glucose 6 phosphate dehydrogenase (G6PD) deficiency * A history of cancer, diabetes, or any other chronic disease * A history of any heart disease * A history of hormone therapy * Use of nicotine products * Pregnancy * Nursing mothers * Participation in regular physical activity greater than 1 day/week- but less than 4 days/week

Inclusion Criteria

Exclusion Criteria

* Healthy individuals (age 21-45) who are either sedentary (1 or less days of exercise per week during past year) or habitually active (4 or more days of aerobic exercise per week for a minimum of 1 year)

* Body mass index \<18 or \>35
* Systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90
* Blood donation within past 8 weeks,
* Glucose 6 phosphate dehydrogenase (G6PD) deficiency
* A history of cancer, diabetes, or any other chronic disease
* A history of any heart disease
* A history of hormone therapy
* Use of nicotine products
* Pregnancy
* Nursing mothers
* Participation in regular physical activity greater than 1 day/week- but less than 4 days/week

Contacts and Locations

Study Contact

David G Edwards, PhD

CONTACT

302-831-3363

dge@udel.edu

Jordan C Patik, PhD

CONTACT

512-820-6387

jpatik@udel.edu

Principal Investigator

David G Edwards, PhD

PRINCIPAL_INVESTIGATOR

University of Delaware

Study Locations (Sites)

Department of Kinesiology and Applied Physiology, University of Delaware

Newark, Delaware, 19713

United States

Collaborators and Investigators

Sponsor: University of Delaware

David G Edwards, PhD, PRINCIPAL_INVESTIGATOR, University of Delaware

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-01-01

Study Completion Date2024-12-31

Study Record Updates

Study Start Date2020-01-01

Study Completion Date2024-12-31

Terms related to this study

Keywords Provided by Researchers

endothelium
oxidative stress
physical activity
ventricular-vascular coupling
pulsatile load

Additional Relevant MeSH Terms

Sodium Excess