Dietary Sodium, Oxidative Stress, and Pulsatile Hemodynamics

Description

High sodium diets impair vascular function, which may influence the work of the heart. This investigation is designed to determine if this change in vascular function results in a greater workload in the heart and if people who regularly exercise are protected from these effects.

Conditions

Sodium Excess

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Study Overview

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Study Details

Study overview

High sodium diets impair vascular function, which may influence the work of the heart. This investigation is designed to determine if this change in vascular function results in a greater workload in the heart and if people who regularly exercise are protected from these effects.

The Role of Oxidative Stress and Endothelial Dysfunction in High Sodium-Induced Changes in Pulsatile Hemodynamics

Dietary Sodium, Oxidative Stress, and Pulsatile Hemodynamics

Condition
Sodium Excess
Intervention / Treatment

-

Contacts and Locations

Newark

Department of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, United States, 19713

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Healthy individuals (age 21-45) who are either sedentary (1 or less days of exercise per week during past year) or habitually active (4 or more days of aerobic exercise per week for a minimum of 1 year)
  • * Body mass index \<18 or \>35
  • * Systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90
  • * Blood donation within past 8 weeks,
  • * Glucose 6 phosphate dehydrogenase (G6PD) deficiency
  • * A history of cancer, diabetes, or any other chronic disease
  • * A history of any heart disease
  • * A history of hormone therapy
  • * Use of nicotine products
  • * Pregnancy
  • * Nursing mothers
  • * Participation in regular physical activity greater than 1 day/week- but less than 4 days/week

Ages Eligible for Study

21 Years to 45 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Delaware,

David G Edwards, PhD, PRINCIPAL_INVESTIGATOR, University of Delaware

Study Record Dates

2024-12-31