RECRUITING

The Effect of Fluids on Aortic VTI During C-section

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Pregnancy is associated with a myriad of physiologic changes, including expansion of blood volume, decrease in oncotic pressure, and increased cardiac output. The obstetric population is associated with intrapartum hemorrhage. Accordingly, it is important to have an accurate method to assess fluid status in intrapartum patients. The use of standard volume assessment tools including arterial lines and central venous catheters is limited given the brevity of obstetric procedures and the morbidity of these techniques on the awake patients, and the costs. Non-invasive methods to assess volume status (carotid dopplers, direct measurement of blood loss, bio-impedance devices) are imperfect. Echocardiography is an attractive tool to measure fluid status in experienced operators such as anesthesiologists. IVC diameter and variation of aortic velocity time integral are two measures that can be obtained via echocardiography and been studied in spontaneously breathing patients. The purpose of this study is to determine whether these measurements can be used in the assessment of volume status in the laboring patient.

Official Title

The Influence of Intravascular Fluid Administration on Aortic Velocity Time Integral in Obstetric Patients Undergoing Cesarean Section

Quick Facts

Study Start:2020-03-25
Study Completion:2025-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04330742

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 35 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * healthy nulliparous or multiparous pregnant women with a term (\>37 weeks gestation)
  2. * age 18-35
  3. * singleton pregnancy
  4. * scheduled for Cesarean delivery with planned neuraxial spinal or combined spinal epidural anesthesia
  5. * American Society for Anesthesiologists physical status 2
  1. * Patients without ability to provide informed consent
  2. * American Society for Anesthesiologists physical status 3 or 4
  3. * Emergency cesarean section
  4. * BMI\>40
  5. * Known cardiac and pulmonary comorbidities including chronic hypertension, preeclampsia, gestational hypertension, diabetes, asthma, renal disease
  6. * Age \> 35

Contacts and Locations

Study Contact

Amy Lee, MD
CONTACT
713-793-8805
amy.lee@bcm.edu
Claudia Wei, MD
CONTACT
cwei@bcm.edu

Principal Investigator

Amy Lee, MD
PRINCIPAL_INVESTIGATOR
Baylor College of Medicine
Yi Deng, MD
STUDY_DIRECTOR
Baylor College of Medicine
Claudia Wei, MD
PRINCIPAL_INVESTIGATOR
Baylor College of Medicine

Study Locations (Sites)

Ben Taub General Hospital
Houston, Texas, 77030
United States

Collaborators and Investigators

Sponsor: Baylor College of Medicine

  • Amy Lee, MD, PRINCIPAL_INVESTIGATOR, Baylor College of Medicine
  • Yi Deng, MD, STUDY_DIRECTOR, Baylor College of Medicine
  • Claudia Wei, MD, PRINCIPAL_INVESTIGATOR, Baylor College of Medicine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-03-25
Study Completion Date2025-12-31

Study Record Updates

Study Start Date2020-03-25
Study Completion Date2025-12-31

Terms related to this study

Keywords Provided by Researchers

  • obstetrics
  • fluid responsiveness
  • fluid resuscitation

Additional Relevant MeSH Terms

  • Pregnancy Related
  • Hemorrhage
  • Fluid Overload
  • Labor Complication