RECRUITING

The Influence of Mitochondrial-Derived Reactive Oxygen Species on Racial Disparities in Neurovascular Function

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Black individuals are at increased cardiovascular disease risk. The central goal of the study is to determine if mitochondrial reactive oxygen species influence blood vessel function and nervous system regulation of blood pressure differentially in black, compared to white individuals. These findings may help to explain a potential mechanism that contributes to racial disparities in blood pressure and cardiovascular disease risk. A secondary goal is to determine if mitochondrial reactive oxygen species improves blood pressure and vascular function in individuals with elevated blood pressure and stage 1 hypertension.

Official Title

The Influence of Mitochondrial-Derived Reactive Oxygen Species on Racial Disparities in Neurovascular Function

Quick Facts

Study Start:2020-10-02
Study Completion:2025-08-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04334135

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:19 Years to 75 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Are between the ages of 19-75.
  2. * Have blood pressure no higher than 150/90 mmHg.
  3. * Have a BMI below 35 Kg/m2 (otherwise healthy)
  4. * Free from metabolic disease (diabetes or renal disease), pulmonary disorders (e.g., COPD \& cystic fibrosis), and cardiovascular disease (peripheral vascular, cardiac, or cerebrovascular).
  5. * Do not have any precluding medical issues that prevent participants from exercising (i.e., cardiovascular issues, or muscle/joint issues including painful arthritis) or giving blood (e.g., blood thinners).
  6. * Are not currently smoking, using smokeless tobacco, nor smoked within the past 12 months.
  1. * Known allergy to MitoQ
  2. * High blood pressure - greater the 150/90 mmHg
  3. * Low blood pressure - less than 90/50 mmHg
  4. * History of cardiovascular disease
  5. * History of cancer
  6. * History of diabetes
  7. * History of kidney disease
  8. * Obesity (BMI \> 30 kg/m2)
  9. * Smoking or tobacco use
  10. * Current pregnancy
  11. * Nursing mothers
  12. * Communication barriers

Contacts and Locations

Study Contact

Austin T Robinson, PhD
CONTACT
334 844 1619
atr0026@auburn.edu
Zachary J Hutchison, MS
CONTACT
zzh0026@auburn.edu

Study Locations (Sites)

Kinesiology Building
Auburn, Alabama, 36849
United States

Collaborators and Investigators

Sponsor: Auburn University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-10-02
Study Completion Date2025-08-31

Study Record Updates

Study Start Date2020-10-02
Study Completion Date2025-08-31

Terms related to this study

Keywords Provided by Researchers

  • blood pressure
  • hypertension
  • cardiovascular health
  • renal function
  • health disparities

Additional Relevant MeSH Terms

  • Racial Disparities
  • Blood Pressure
  • Cardiovascular Risk Factor
  • Renal Function