The Influence of Mitochondrial-Derived Reactive Oxygen Species on Racial Disparities in Neurovascular Function

Description

Black individuals are at increased cardiovascular disease risk. The central goal of the study is to determine if mitochondrial reactive oxygen species influence blood vessel function and nervous system regulation of blood pressure differentially in black, compared to white individuals. These findings may help to explain a potential mechanism that contributes to racial disparities in blood pressure and cardiovascular disease risk. A secondary goal is to determine if mitochondrial reactive oxygen species improves blood pressure and vascular function in individuals with elevated blood pressure and stage 1 hypertension.

Conditions

Racial Disparities, Blood Pressure, Cardiovascular Risk Factor, Renal Function

Study Overview

Study Details

Study overview

Black individuals are at increased cardiovascular disease risk. The central goal of the study is to determine if mitochondrial reactive oxygen species influence blood vessel function and nervous system regulation of blood pressure differentially in black, compared to white individuals. These findings may help to explain a potential mechanism that contributes to racial disparities in blood pressure and cardiovascular disease risk. A secondary goal is to determine if mitochondrial reactive oxygen species improves blood pressure and vascular function in individuals with elevated blood pressure and stage 1 hypertension.

The Influence of Mitochondrial-Derived Reactive Oxygen Species on Racial Disparities in Neurovascular Function

The Influence of Mitochondrial-Derived Reactive Oxygen Species on Racial Disparities in Neurovascular Function

Condition
Racial Disparities
Intervention / Treatment

-

Contacts and Locations

Auburn

Kinesiology Building, Auburn, Alabama, United States, 36849

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Are between the ages of 19-75.
  • * Have blood pressure no higher than 150/90 mmHg.
  • * Have a BMI below 35 Kg/m2 (otherwise healthy)
  • * Free from metabolic disease (diabetes or renal disease), pulmonary disorders (e.g., COPD \& cystic fibrosis), and cardiovascular disease (peripheral vascular, cardiac, or cerebrovascular).
  • * Do not have any precluding medical issues that prevent participants from exercising (i.e., cardiovascular issues, or muscle/joint issues including painful arthritis) or giving blood (e.g., blood thinners).
  • * Are not currently smoking, using smokeless tobacco, nor smoked within the past 12 months.
  • * Known allergy to MitoQ
  • * High blood pressure - greater the 150/90 mmHg
  • * Low blood pressure - less than 90/50 mmHg
  • * History of cardiovascular disease
  • * History of cancer
  • * History of diabetes
  • * History of kidney disease
  • * Obesity (BMI \> 30 kg/m2)
  • * Smoking or tobacco use
  • * Current pregnancy
  • * Nursing mothers
  • * Communication barriers

Ages Eligible for Study

19 Years to 75 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Auburn University,

Study Record Dates

2025-08-31