RECRUITING

Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) women. Specifically, aim one will determine mechanisms driving autonomic dysregulation of BP in premature and early menopausal women and aim two will determine mechanisms driving autonomic dysregulation of BP in older menopausal women. The study design outlined below will permit testing of aim one and aim two.

Official Title

Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women

Quick Facts

Study Start:2019-10-01
Study Completion:2025-04-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04439370

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:35 Years to 70 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Aged 35-49 or 50-70 years of age who experienced premature (\<40) or early (≤45) menopause
  2. * Premenopausal 35-49 years of age
  3. * Typical-age menopause (i.e., after 45 years of age), who are between 50-70 years old
  4. * Menopause will be confirmed by subject report of amenorrhea for 12 months and serum FSH of \>30 mIU/mL
  1. * Current nicotine/tobacco use within the past six months
  2. * Are diabetic or asthmatic
  3. * Have diagnosed significant carotid stenosis
  4. * Have a history of significant autonomic dysfunction, heart disease, respiratory disease or a severe neurologic condition such as stroke or traumatic brain injury.
  5. * Have existing metabolic or endocrine abnormities
  6. * Take any heart/blood pressure medications that are determined to interfere with study outcomes
  7. * IF the participant is premenopausal AND currently taking OC or other exogenous steroids that are determined to interfere with study outcomes
  8. * Females who classify as having early or premature menopause AND are not willing to discontinue OC or MHT in order to complete the study
  9. * Are pregnant or breastfeeding

Contacts and Locations

Study Contact

Manda Keller-Ross, PhD, DPT, PT
CONTACT
612-625-3175
kell0529@umn.edu

Study Locations (Sites)

University of Minnesota
Minneapolis, Minnesota, 55455
United States

Collaborators and Investigators

Sponsor: University of Minnesota

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2019-10-01
Study Completion Date2025-04-30

Study Record Updates

Study Start Date2019-10-01
Study Completion Date2025-04-30

Terms related to this study

Additional Relevant MeSH Terms

  • Hypertension
  • Menopause, Premature
  • Menopause
  • Blood Pressure