Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women

Description

This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) women. Specifically, aim one will determine mechanisms driving autonomic dysregulation of BP in premature and early menopausal women and aim two will determine mechanisms driving autonomic dysregulation of BP in older menopausal women. The study design outlined below will permit testing of aim one and aim two.

Conditions

Hypertension, Menopause, Premature, Menopause, Blood Pressure

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Study Overview

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Study Details

Study overview

This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) women. Specifically, aim one will determine mechanisms driving autonomic dysregulation of BP in premature and early menopausal women and aim two will determine mechanisms driving autonomic dysregulation of BP in older menopausal women. The study design outlined below will permit testing of aim one and aim two.

Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women

Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women

Condition
Hypertension
Intervention / Treatment

-

Contacts and Locations

Minneapolis

University of Minnesota, Minneapolis, Minnesota, United States, 55455

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Aged 35-49 or 50-70 years of age who experienced premature (\<40) or early (≤45) menopause
  • * Premenopausal 35-49 years of age
  • * Typical-age menopause (i.e., after 45 years of age), who are between 50-70 years old
  • * Menopause will be confirmed by subject report of amenorrhea for 12 months and serum FSH of \>30 mIU/mL
  • * Current nicotine/tobacco use within the past six months
  • * Are diabetic or asthmatic
  • * Have diagnosed significant carotid stenosis
  • * Have a history of significant autonomic dysfunction, heart disease, respiratory disease or a severe neurologic condition such as stroke or traumatic brain injury.
  • * Have existing metabolic or endocrine abnormities
  • * Take any heart/blood pressure medications that are determined to interfere with study outcomes
  • * IF the participant is premenopausal AND currently taking OC or other exogenous steroids that are determined to interfere with study outcomes
  • * Females who classify as having early or premature menopause AND are not willing to discontinue OC or MHT in order to complete the study
  • * Are pregnant or breastfeeding

Ages Eligible for Study

35 Years to 70 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Minnesota,

Study Record Dates

2025-04-30