RECRUITING

Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The proposed study is designed to test the hypothesis that treatment of resveratrol for 12 weeks will improve both endothelin-B receptor (aim 1) and skeletal muscle mitochondrial function (aim 2) in people with type 1 diabetes.

Official Title

Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1

Quick Facts

Study Start:2020-10-14
Study Completion:2025-07-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04449198

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Men and premenopausal women
  2. * All races
  3. * Clinical diagnosis of insulin-dependent type 1 diabetes (patients only)
  1. * Clinical diagnosis of hepatic, cardiovascular, or renal disease
  2. * Uncontrolled diabetes (HbA1C \>12%)
  3. * Diabetic complications (i.e. neuropathy)
  4. * Uncontrolled hypertension (\>140/90 mm Hg on therapy)
  5. * Pregnancy
  6. * Use of vasoactive medications

Contacts and Locations

Study Contact

Ryan A Harris, PhD, CEP
CONTACT
7067215998
ryharris@augusta.edu
Jacob Looney, MS
CONTACT
7067215483
jlooney@augusta.edu

Study Locations (Sites)

Augusta University/Georgia Prevention Institute/ Laboratory of Integrative and Exercise Physiology
Augusta, Georgia, 30912
United States

Collaborators and Investigators

Sponsor: Augusta University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-10-14
Study Completion Date2025-07-01

Study Record Updates

Study Start Date2020-10-14
Study Completion Date2025-07-01

Terms related to this study

Keywords Provided by Researchers

  • diabetes
  • heart disease
  • muscle function
  • blood vessels

Additional Relevant MeSH Terms

  • Type 1 Diabetes