Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1

Description

The proposed study is designed to test the hypothesis that treatment of resveratrol for 12 weeks will improve both endothelin-B receptor (aim 1) and skeletal muscle mitochondrial function (aim 2) in people with type 1 diabetes.

Conditions

Type 1 Diabetes

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Study Overview

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Study Details

Study overview

The proposed study is designed to test the hypothesis that treatment of resveratrol for 12 weeks will improve both endothelin-B receptor (aim 1) and skeletal muscle mitochondrial function (aim 2) in people with type 1 diabetes.

Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1

Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1

Condition
Type 1 Diabetes
Intervention / Treatment

-

Contacts and Locations

Augusta

Augusta University/Georgia Prevention Institute/ Laboratory of Integrative and Exercise Physiology, Augusta, Georgia, United States, 30912

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Men and premenopausal women
  • * All races
  • * Clinical diagnosis of insulin-dependent type 1 diabetes (patients only)
  • * Clinical diagnosis of hepatic, cardiovascular, or renal disease
  • * Uncontrolled diabetes (HbA1C \>12%)
  • * Diabetic complications (i.e. neuropathy)
  • * Uncontrolled hypertension (\>140/90 mm Hg on therapy)
  • * Pregnancy
  • * Use of vasoactive medications

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Augusta University,

Study Record Dates

2025-07-01