RECRUITING

Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Spermatogonial stem cell transplantation through ultrasound guided rete testis injection and testicular tissue grafting will be performed for participants who have frozen testicular tissue prior to gonadotoxic therapy. The purpose of this study is to test the safety and feasibility of these transplant technologies and restore fertility for these participants.

Official Title

Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting

Quick Facts

Study Start:2023-11-10
Study Completion:2026-07-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04452305

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:Not specified
Sexes Eligible for Study:MALE
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Male participant at least in Tanner stage 3
  2. * Previously cryopreserved and stored testicular tissue/cells (frozen due to an infertility-risking diagnosis or treatment such as chemotherapy or radiation) available for autologous transplantation and grafting
  3. * Healthy enough to undergo anesthesia
  4. * Written clearance for the procedure from the patient's hematologist or oncologist to confirm the patient has finished treatment for primary condition and are clear to undergo autologous stem cell transplant
  1. * Participants considered to be high risk for surgical complications
  2. * Participants with a history of leukemia, lymphoma or testicular cancer or a cancer that likely involved testicles at the time of testicular tissue collection
  3. * Diagnosed with psychological, psychiatric, or other conditions which prevent giving fully informed consent.

Contacts and Locations

Study Contact

Rachel Neelley
CONTACT
412-641-7475
fertilitypreservation@upmc.edu

Principal Investigator

Kyle E Orwig, PhD
PRINCIPAL_INVESTIGATOR
University of Pittsburgh

Study Locations (Sites)

Magee-Womens Hospital
Pittsburgh, Pennsylvania, 15213
United States

Collaborators and Investigators

Sponsor: University of Pittsburgh

  • Kyle E Orwig, PhD, PRINCIPAL_INVESTIGATOR, University of Pittsburgh

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-11-10
Study Completion Date2026-07-01

Study Record Updates

Study Start Date2023-11-10
Study Completion Date2026-07-01

Terms related to this study

Keywords Provided by Researchers

  • spermatogonial stem cells
  • testis
  • fertility
  • oncofertility

Additional Relevant MeSH Terms

  • Infertility, Male
  • Cancer
  • Autoimmune Disorder