Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting

Description

Spermatogonial stem cell transplantation through ultrasound guided rete testis injection and testicular tissue grafting will be performed for participants who have frozen testicular tissue prior to gonadotoxic therapy. The purpose of this study is to test the safety and feasibility of these transplant technologies and restore fertility for these participants.

Conditions

Infertility, Male, Cancer, Autoimmune Disorder

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Study Overview

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Study Details

Study overview

Spermatogonial stem cell transplantation through ultrasound guided rete testis injection and testicular tissue grafting will be performed for participants who have frozen testicular tissue prior to gonadotoxic therapy. The purpose of this study is to test the safety and feasibility of these transplant technologies and restore fertility for these participants.

Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting

Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting

Condition
Infertility, Male
Intervention / Treatment

-

Contacts and Locations

Pittsburgh

Magee-Womens Hospital, Pittsburgh, Pennsylvania, United States, 15213

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Male participant at least in Tanner stage 3
  • * Previously cryopreserved and stored testicular tissue/cells (frozen due to an infertility-risking diagnosis or treatment such as chemotherapy or radiation) available for autologous transplantation and grafting
  • * Healthy enough to undergo anesthesia
  • * Written clearance for the procedure from the patient's hematologist or oncologist to confirm the patient has finished treatment for primary condition and are clear to undergo autologous stem cell transplant
  • * Participants considered to be high risk for surgical complications
  • * Participants with a history of leukemia, lymphoma or testicular cancer or a cancer that likely involved testicles at the time of testicular tissue collection
  • * Diagnosed with psychological, psychiatric, or other conditions which prevent giving fully informed consent.

Ages Eligible for Study

to

Sexes Eligible for Study

MALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Pittsburgh,

Kyle E Orwig, PhD, PRINCIPAL_INVESTIGATOR, University of Pittsburgh

Study Record Dates

2026-07-01