RECRUITING

Transcranial Magnetic Stimulation in Progressive Supranuclear Palsy

Description

The objective of this proposal is to investigate the effect of non-invasive repetitive cerebellar transcranial magnetic stimulation (rTMS) on motor control in progressive supranuclear (PSP). The central hypothesis is that augmenting cerebellar inhibition via cerebellar rTMS will decrease postural instability in patients with PSP. We will use functional near infrared spectroscopy (fNIRS) to examine changes in motor and premotor cortical activity after cerebellar rTMS.

Conditions

Palsy SupranuclearSupranuclear Palsy, Progressive
Talk to us

Related Conditions:

Palsy SupranuclearSupranuclear Palsy, Progressive

Study Overview

On this page

Study Details

Study overview

The objective of this proposal is to investigate the effect of non-invasive repetitive cerebellar transcranial magnetic stimulation (rTMS) on motor control in progressive supranuclear (PSP). The central hypothesis is that augmenting cerebellar inhibition via cerebellar rTMS will decrease postural instability in patients with PSP. We will use functional near infrared spectroscopy (fNIRS) to examine changes in motor and premotor cortical activity after cerebellar rTMS.

Cerebellar Transcranial Magnetic Stimulation for Motor Control in Progressive Supranuclear Palsy

Transcranial Magnetic Stimulation in Progressive Supranuclear Palsy

Condition
Palsy Supranuclear
Intervention / Treatment

-

Contacts and Locations

Portland

Oregon Health & Science University, Portland, Oregon, United States, 97239

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * probable or possible PSP by the revised MDS PSP Criteria (Hoglinger 2017)
  • * age 40-85 at time of screening
  • * ability to understand and cooperate with simple instructions in English
  • * ability to read at 6th grade reading level in English
  • * ability to stand unassisted for at least 30 seconds and to be able walk independently with a walker
  • * ability to refrain from new physical and speech therapy programs for the duration of the study
  • * ability to remain on stable doses of any cholinergic, dopaminergic, serotonergic sedative or NMDA receptor antagonists for the duration of the study
  • * females of child-bearing age must perform a urine pregnancy test and be on reliable birth control during the course of the study
  • * other significant neurological or vestibular disorders
  • * presence of electrically, magnetically or mechanically activated implants or history of injurious metal exposure in eyes, head, or body

Ages Eligible for Study

40 Years to 85 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Oregon Health and Science University,

Marian L Dale, MD, MCR, PRINCIPAL_INVESTIGATOR, Oregon Health and Science University

Study Record Dates

2027-04-20