RECRUITING

Transcranial Magnetic Stimulation in Progressive Supranuclear Palsy

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Conditions

Palsy SupranuclearSupranuclear Palsy, Progressiverepetitive transcranial magnetic stimulation

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The objective of this proposal is to investigate the effect of non-invasive repetitive cerebellar transcranial magnetic stimulation (rTMS) on motor control in progressive supranuclear (PSP). The central hypothesis is that augmenting cerebellar inhibition via cerebellar rTMS will decrease postural instability in patients with PSP. We will use functional near infrared spectroscopy (fNIRS) to examine changes in motor and premotor cortical activity after cerebellar rTMS.

Official Title

Cerebellar Transcranial Magnetic Stimulation for Motor Control in Progressive Supranuclear Palsy

Quick Facts

Study Start:2020-01-17
Study Completion:2027-04-20
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04468932

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:40 Years to 85 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * probable or possible PSP by the revised MDS PSP Criteria (Hoglinger 2017)
  2. * age 40-85 at time of screening
  3. * ability to understand and cooperate with simple instructions in English
  4. * ability to read at 6th grade reading level in English
  5. * ability to stand unassisted for at least 30 seconds and to be able walk independently with a walker
  6. * ability to refrain from new physical and speech therapy programs for the duration of the study
  7. * ability to remain on stable doses of any cholinergic, dopaminergic, serotonergic sedative or NMDA receptor antagonists for the duration of the study
  8. * females of child-bearing age must perform a urine pregnancy test and be on reliable birth control during the course of the study
  1. * other significant neurological or vestibular disorders
  2. * presence of electrically, magnetically or mechanically activated implants or history of injurious metal exposure in eyes, head, or body

Contacts and Locations

Study Contact

Graham Harker
CONTACT
5034182601
balance@ohsu.edu

Principal Investigator

Marian L Dale, MD, MCR
PRINCIPAL_INVESTIGATOR
Oregon Health and Science University

Study Locations (Sites)

Oregon Health & Science University
Portland, Oregon, 97239
United States

Collaborators and Investigators

Sponsor: Oregon Health and Science University

  • Marian L Dale, MD, MCR, PRINCIPAL_INVESTIGATOR, Oregon Health and Science University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-01-17
Study Completion Date2027-04-20

Study Record Updates

Study Start Date2020-01-17
Study Completion Date2027-04-20

Terms related to this study

Keywords Provided by Researchers

  • repetitive transcranial magnetic stimulation

Additional Relevant MeSH Terms

  • Palsy Supranuclear
  • Supranuclear Palsy, Progressive