TERMINATED

Comparison of Potassium Binders in the ER

Conditions

Acute Hyperkalemia Oral Potassium Binders Emergency Department

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Compare efficacy of 3 oral potassium binders (cation exchange resins) on lowering blood potassium, in hospital patients with acute hyperkalemia.

Official Title

Comparison of Potassium Binders in the ER

Quick Facts

Study Start:2020-10-20

Study Completion:2025-01-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:TERMINATED

Study ID

NCT04585542

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Plasma potassium \> 5.5 mEq/L * Age ≥18 years * Patient able to provide written informed consent	* Recent bowel surgery * Ileus or bowel obstruction * Pseudohyperkalemia signs and symptoms, such as excessive fist clenching, hemolyzed blood specimen, severe leukocytosis or thrombocytosis * Pregnancy * Active psychiatric disorder * Diabetic ketoacidosis or hyperkalemia caused by any condition for which a therapy directed against the underlying cause of hyperkalemia would be a better treatment option * Dialysis session expected within 4 hours after randomization * History of hypersensitivity to sodium polystyrene sulfonate resin or patiromer * Concurrent use of sorbitol (due to increased risk of intestinal necrosis when used with sodium polystyrene sulfonate)

Inclusion Criteria

Exclusion Criteria

* Plasma potassium \> 5.5 mEq/L
* Age ≥18 years
* Patient able to provide written informed consent

* Recent bowel surgery
* Ileus or bowel obstruction
* Pseudohyperkalemia signs and symptoms, such as excessive fist clenching, hemolyzed blood specimen, severe leukocytosis or thrombocytosis
* Pregnancy
* Active psychiatric disorder
* Diabetic ketoacidosis or hyperkalemia caused by any condition for which a therapy directed against the underlying cause of hyperkalemia would be a better treatment option
* Dialysis session expected within 4 hours after randomization
* History of hypersensitivity to sodium polystyrene sulfonate resin or patiromer
* Concurrent use of sorbitol (due to increased risk of intestinal necrosis when used with sodium polystyrene sulfonate)

Contacts and Locations

Study Locations (Sites)

University of California, Irvine Medical Center

Orange, California, 92868

United States

Collaborators and Investigators

Sponsor: University of California, Irvine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-10-20

Study Completion Date2025-01-31

Study Record Updates

Study Start Date2020-10-20

Study Completion Date2025-01-31

Terms related to this study

Keywords Provided by Researchers

Emergency Department

Additional Relevant MeSH Terms

Acute Hyperkalemia
Oral Potassium Binders