Comparison of Potassium Binders in the ER

Description

Compare efficacy of 3 oral potassium binders (cation exchange resins) on lowering blood potassium, in hospital patients with acute hyperkalemia.

Conditions

Acute Hyperkalemia, Oral Potassium Binders

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Study Overview

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Study Details

Study overview

Compare efficacy of 3 oral potassium binders (cation exchange resins) on lowering blood potassium, in hospital patients with acute hyperkalemia.

Comparison of Potassium Binders in the ER

Comparison of Potassium Binders in the ER

Condition
Acute Hyperkalemia
Intervention / Treatment

-

Contacts and Locations

Orange

University of California, Irvine Medical Center, Orange, California, United States, 92868

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Plasma potassium \> 5.5 mEq/L
  • * Age ≥18 years
  • * Patient able to provide written informed consent
  • * Recent bowel surgery
  • * Ileus or bowel obstruction
  • * Pseudohyperkalemia signs and symptoms, such as excessive fist clenching, hemolyzed blood specimen, severe leukocytosis or thrombocytosis
  • * Pregnancy
  • * Active psychiatric disorder
  • * Diabetic ketoacidosis or hyperkalemia caused by any condition for which a therapy directed against the underlying cause of hyperkalemia would be a better treatment option
  • * Dialysis session expected within 4 hours after randomization
  • * History of hypersensitivity to sodium polystyrene sulfonate resin or patiromer
  • * Concurrent use of sorbitol (due to increased risk of intestinal necrosis when used with sodium polystyrene sulfonate)

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, Irvine,

Study Record Dates

2025-12-01