RECRUITING

Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

Conditions

Asthma COPD Interstitial Lung Disease Cystic Fibrosis Pulmonary Hypertension Pulmonary Infection Other Lung Disease Hyperpolarized 129Xe MRI

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to develop and evaluate the usefulness of hyperpolarized (HP) 129Xe gas MRI for regional assessment of pulmonary function.

Official Title

Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

Quick Facts

Study Start:2020-11-02

Study Completion:2026-10-26

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT04624490

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:3 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:CHILD, ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Subject has no diagnosed pulmonary conditions * Ability to read and understand English or Spanish * Subject has a diagnosis of pulmonary dysfunction made by a physician * No acute worsening of pulmonary function in the past 30 days * Ability to read and understand English or Spanish	* MRI is contraindicated based on responses to MRI screening questionnaire * Subject is pregnant or lactating * Subject does not fit into 129Xe vest coil used for MRI * Subject cannot hold his/her breath for 15-16 seconds * Subject deemed unlikely to be able to comply with instructions during imaging * Oxygen saturation \<88% on room air or with supplemental oxygen * Cognitive deficits that preclude ability to provide consent * Institutionalization

Inclusion Criteria

Exclusion Criteria

* Subject has no diagnosed pulmonary conditions
* Ability to read and understand English or Spanish
* Subject has a diagnosis of pulmonary dysfunction made by a physician
* No acute worsening of pulmonary function in the past 30 days
* Ability to read and understand English or Spanish

* MRI is contraindicated based on responses to MRI screening questionnaire
* Subject is pregnant or lactating
* Subject does not fit into 129Xe vest coil used for MRI
* Subject cannot hold his/her breath for 15-16 seconds
* Subject deemed unlikely to be able to comply with instructions during imaging
* Oxygen saturation \<88% on room air or with supplemental oxygen
* Cognitive deficits that preclude ability to provide consent
* Institutionalization

Contacts and Locations

Study Contact

Cristal Monge

CONTACT

913-945-9399

chernandez@kumc.edu

Principal Investigator

Peter Niedbalski, PHD

PRINCIPAL_INVESTIGATOR

University of Kansas Medical Center

Study Locations (Sites)

University of Kansas Medical Center

Kansas City, Kansas, 66160

United States

Collaborators and Investigators

Sponsor: Mario Castro, MD, MPH

Peter Niedbalski, PHD, PRINCIPAL_INVESTIGATOR, University of Kansas Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-11-02

Study Completion Date2026-10-26

Study Record Updates

Study Start Date2020-11-02

Study Completion Date2026-10-26

Terms related to this study

Keywords Provided by Researchers

Hyperpolarized 129Xe MRI

Additional Relevant MeSH Terms

Asthma
COPD
Interstitial Lung Disease
Cystic Fibrosis
Pulmonary Hypertension
Pulmonary Infection
Other Lung Disease