Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

Description

The purpose of this study is to develop and evaluate the usefulness of hyperpolarized (HP) 129Xe gas MRI for regional assessment of pulmonary function.

Conditions

Asthma, COPD, Interstitial Lung Disease, Cystic Fibrosis, Pulmonary Hypertension, Pulmonary Infection, Other Lung Disease

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Study Overview

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Study Details

Study overview

The purpose of this study is to develop and evaluate the usefulness of hyperpolarized (HP) 129Xe gas MRI for regional assessment of pulmonary function.

Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

Condition
Asthma
Intervention / Treatment

-

Contacts and Locations

Kansas City

University of Kansas Medical Center, Kansas City, Kansas, United States, 66160

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Subject has no diagnosed pulmonary conditions
  • * Ability to read and understand English or Spanish
  • * Subject has a diagnosis of pulmonary dysfunction made by a physician
  • * No acute worsening of pulmonary function in the past 30 days
  • * Ability to read and understand English or Spanish
  • * MRI is contraindicated based on responses to MRI screening questionnaire
  • * Subject is pregnant or lactating
  • * Subject does not fit into 129Xe vest coil used for MRI
  • * Subject cannot hold his/her breath for 15-16 seconds
  • * Subject deemed unlikely to be able to comply with instructions during imaging
  • * Oxygen saturation \<88% on room air or with supplemental oxygen
  • * Cognitive deficits that preclude ability to provide consent
  • * Institutionalization

Ages Eligible for Study

3 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Mario Castro, MD, MPH,

Peter Niedbalski, PHD, PRINCIPAL_INVESTIGATOR, University of Kansas Medical Center

Study Record Dates

2026-10-26