RECRUITING

Pathogenesis of Pediatric Nonalcoholic Fatty Liver Disease (NAFLD)

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Conditions

NAFLD

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The main aim of the study is to discover the mechanisms underlying the pathophysiology of NAFLD in obese youth.

Official Title

Pathophysiologic Mechanisms Leading to Intrahepatic Fat Accumulation in Obese Youth

Quick Facts

Study Start:2021-06-28
Study Completion:2026-01-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04634643

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:12 Years to 18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Not specified
Standard Ages:CHILD, ADULT
Inclusion CriteriaExclusion Criteria
  1. * Good general health, taking no medication on a chronic basis;
  2. * age 12 to 18 years, in puberty (girls and boys: Tanner stage II-V);
  3. * BMI \>85th for obese cohort;
  1. * Baseline creatinine \>1.0 mg; pregnancy;
  2. * the presence of endocrinopathies (e.g. Cushing syndrome);
  3. * cardiac or pulmonary or other significant chronic illness;
  4. * adolescents with a psychiatric disorder or with substance abuse;
  5. * monogenic obesity syndromes;
  6. * use of drugs affecting intrahepatic fat content (e.g.; liraglutide, fish oil, etc.).

Contacts and Locations

Study Contact

Jessica Lat
CONTACT
jessica.lat@yale.edu
Zhongyao Li
CONTACT
zhongyao.li@yale.edu

Principal Investigator

Nicola Santoro, MD, PhD
PRINCIPAL_INVESTIGATOR
Associate Professor of Pediatrics (Endocrinology)

Study Locations (Sites)

Yale New Haven Hospital
New Haven, Connecticut, 06510
United States

Collaborators and Investigators

Sponsor: Yale University

  • Nicola Santoro, MD, PhD, PRINCIPAL_INVESTIGATOR, Associate Professor of Pediatrics (Endocrinology)

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-06-28
Study Completion Date2026-01-30

Study Record Updates

Study Start Date2021-06-28
Study Completion Date2026-01-30

Terms related to this study

Additional Relevant MeSH Terms

  • NAFLD