Pathogenesis of Pediatric Nonalcoholic Fatty Liver Disease (NAFLD)

Description

The main aim of the study is to discover the mechanisms underlying the pathophysiology of NAFLD in obese youth.

Conditions

NAFLD

Talk to us

Study Overview

On this page

Study Details

Study overview

The main aim of the study is to discover the mechanisms underlying the pathophysiology of NAFLD in obese youth.

Pathophysiologic Mechanisms Leading to Intrahepatic Fat Accumulation in Obese Youth

Pathogenesis of Pediatric Nonalcoholic Fatty Liver Disease (NAFLD)

Condition
NAFLD
Intervention / Treatment

-

Contacts and Locations

New Haven

Yale New Haven Hospital, New Haven, Connecticut, United States, 06510

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Good general health, taking no medication on a chronic basis;
  • * age 12 to 18 years, in puberty (girls and boys: Tanner stage II-V);
  • * BMI \>85th for obese cohort;
  • * Baseline creatinine \>1.0 mg; pregnancy;
  • * the presence of endocrinopathies (e.g. Cushing syndrome);
  • * cardiac or pulmonary or other significant chronic illness;
  • * adolescents with a psychiatric disorder or with substance abuse;
  • * monogenic obesity syndromes;
  • * use of drugs affecting intrahepatic fat content (e.g.; liraglutide, fish oil, etc.).

Ages Eligible for Study

12 Years to 18 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Yale University,

Nicola Santoro, MD, PhD, PRINCIPAL_INVESTIGATOR, Associate Professor of Pediatrics (Endocrinology)

Study Record Dates

2026-01-30