RECRUITING

The Precision CAD Trial

Description

People with Coronary Artery Disease (CAD) have narrow or blocked arteries that supply blood to the heart. Reduced blood flow to the heart muscle from CAD can cause chest pain or aching, especially with exercise or activity. CAD can lead to weakening of the heart muscle or heart failure, and a higher risk of heart attack or death. Certain proteins in the blood, known as biomarkers, can be found in people with CAD. Higher levels of these biomarkers are associated with a greater risk of complications from CAD. The purpose of this study is to see if a customized treatment based on biomarkers will reduce the biomarker levels and lead to lower risk of complications from CAD.

Conditions

Coronary Artery Disease
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Related Conditions:

Coronary Artery Disease

Study Overview

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Study Details

Study overview

People with Coronary Artery Disease (CAD) have narrow or blocked arteries that supply blood to the heart. Reduced blood flow to the heart muscle from CAD can cause chest pain or aching, especially with exercise or activity. CAD can lead to weakening of the heart muscle or heart failure, and a higher risk of heart attack or death. Certain proteins in the blood, known as biomarkers, can be found in people with CAD. Higher levels of these biomarkers are associated with a greater risk of complications from CAD. The purpose of this study is to see if a customized treatment based on biomarkers will reduce the biomarker levels and lead to lower risk of complications from CAD.

Use of Biomarker Risk Score to Optimize Therapy in Patients With Coronary Artery Disease: The Precision CAD Trial

The Precision CAD Trial

Condition
Coronary Artery Disease
Intervention / Treatment

-

Contacts and Locations

Atlanta

Emory Johns Creek Hospiatl, Atlanta, Georgia, United States, 30097

Atlanta

Emory University Hospital Midtown, Atlanta, Georgia, United States, 30308

Atlanta

Emory University Hospital, Atlanta, Georgia, United States, 30322

Atlanta

The Emory Clinic, Atlanta, Georgia, United States, 30324

Atlanta

Emory Saint Joseph's Hospital, Atlanta, Georgia, United States, 30342

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Individuals aged 21-90 years with stable CAD.
  • * Patients with any amount of atherosclerosis via coronary angiogram or coronary computed tomography angiography (CCTA).
  • * Patients undergoing revascularization therapy or recent acute coronary syndrome (ACS) will be eligible for recruitment and will be recruited at least 4 weeks after admission for an ACS or percutaneous intervention and 3 months after coronary bypass graft surgery.
  • * Patients with CAC levels ≥ 400
  • * Planned revascularization,
  • * New York Heart Association class III or IV heart failure symptoms,
  • * LVEF \<40%,
  • * eGFR\<45,
  • * Pregnancy, congenital heart disease, severe symptomatic valvular heart disease, active malignancy and cardiac transplant.

Ages Eligible for Study

21 Years to 90 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Emory University,

Arshed Quyyumi, MD, PRINCIPAL_INVESTIGATOR, Emory University

Study Record Dates

2028-12