ACTIVE_NOT_RECRUITING

The Precision CAD Trial

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

People with Coronary Artery Disease (CAD) have narrow or blocked arteries that supply blood to the heart. Reduced blood flow to the heart muscle from CAD can cause chest pain or aching, especially with exercise or activity. CAD can lead to weakening of the heart muscle or heart failure, and a higher risk of heart attack or death. Certain proteins in the blood, known as biomarkers, can be found in people with CAD. Higher levels of these biomarkers are associated with a greater risk of complications from CAD. The purpose of this study is to see if a customized treatment based on biomarkers will reduce the biomarker levels and lead to lower risk of complications from CAD.

Official Title

Use of Biomarker Risk Score to Optimize Therapy in Patients With Coronary Artery Disease: The Precision CAD Trial

Quick Facts

Study Start:2022-10-19
Study Completion:2028-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:ACTIVE_NOT_RECRUITING

Study ID

NCT04755413

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:21 Years to 90 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Individuals aged 21-90 years with stable CAD.
  2. * Patients with any amount of atherosclerosis via coronary angiogram or coronary computed tomography angiography (CCTA).
  3. * Patients undergoing revascularization therapy or recent acute coronary syndrome (ACS) will be eligible for recruitment and will be recruited at least 4 weeks after admission for an ACS or percutaneous intervention and 3 months after coronary bypass graft surgery.
  4. * Patients with CAC levels ≥ 400
  1. * Planned revascularization,
  2. * New York Heart Association class III or IV heart failure symptoms,
  3. * LVEF \<40%,
  4. * eGFR\<45,
  5. * Pregnancy, congenital heart disease, severe symptomatic valvular heart disease, active malignancy and cardiac transplant.

Contacts and Locations

Principal Investigator

Arshed Quyyumi, MD
PRINCIPAL_INVESTIGATOR
Emory University

Study Locations (Sites)

Emory Johns Creek Hospiatl
Atlanta, Georgia, 30097
United States
Emory University Hospital Midtown
Atlanta, Georgia, 30308
United States
Emory University Hospital
Atlanta, Georgia, 30322
United States
The Emory Clinic
Atlanta, Georgia, 30324
United States
Emory Saint Joseph's Hospital
Atlanta, Georgia, 30342
United States

Collaborators and Investigators

Sponsor: Emory University

  • Arshed Quyyumi, MD, PRINCIPAL_INVESTIGATOR, Emory University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-10-19
Study Completion Date2028-12

Study Record Updates

Study Start Date2022-10-19
Study Completion Date2028-12

Terms related to this study

Keywords Provided by Researchers

  • Coronary Artery Disease
  • Biomarkers

Additional Relevant MeSH Terms

  • Coronary Artery Disease