RECRUITING

Improving Care After Inherited Cancer Testing

Description

The IMPACT Study seeks to refine and evaluate the effectiveness of interventions on improving guideline-adherent cancer risk management (CRM) and family communication (FC) of genetic test results for individuals with a documented pathogenic/likely pathogenic (P/LP) variant, and FC of family cancer history for individuals with a variant of uncertain significance (VUS) in an inherited cancer gene.

Conditions

Inherited Cancer SyndromeProstate CancerColorectal CancerEndometrial CancerBreast Cancer
Talk to us

Related Conditions:

Inherited Cancer SyndromeProstate CancerColorectal CancerEndometrial CancerBreast Cancer

Study Overview

On this page

Study Details

Study overview

The IMPACT Study seeks to refine and evaluate the effectiveness of interventions on improving guideline-adherent cancer risk management (CRM) and family communication (FC) of genetic test results for individuals with a documented pathogenic/likely pathogenic (P/LP) variant, and FC of family cancer history for individuals with a variant of uncertain significance (VUS) in an inherited cancer gene.

Improving Care After Inherited Cancer Testing (IMPACT) Study

Improving Care After Inherited Cancer Testing

Condition
Inherited Cancer Syndrome
Intervention / Treatment

-

Contacts and Locations

Nashville

Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, United States, 37212

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * English-speaking men and women aged 18 years or older
  • * Not adopted (i.e., have information about their biological relatives)
  • * Have access to internet and a computer, tablet, or smartphone
  • * Documented pathogenic/likely pathogenic variant in an inherited cancer gene that has CRM guidelines listed in the National Comprehensive Cancer Network (NCCN) Genetic/Familial Panel focused on Breast, Ovarian, and Pancreatic or Colorectal cancers
  • * Must meet at least one of the following criteria:
  • * Intervention A (GeneSHARE) criteria: Have at least one at-risk adult, living relative who either:
  • * has not been told about the genetic test result by the participant
  • * has not had their own genetic testing
  • * Intervention B (LivingLabReport) criteria: Are non-adherent (i.e., either undertreatment or overtreatment) to at least one of the current NCCN CRM guidelines or if currently adherent, require ongoing cancer screening
  • * English-speaking men and women aged 18 years or older
  • * Not adopted (i.e., have information about their biological relatives)
  • * Have access to internet and a computer, tablet, or smartphone
  • * Documented VUS in an inherited cancer gene

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Vanderbilt-Ingram Cancer Center,

Tuya Pal, MD, PRINCIPAL_INVESTIGATOR, Vanderbilt-Ingram Cancer Center

Study Record Dates

2028-12