Improving Care After Inherited Cancer Testing

Description

The IMPACT Study seeks to refine and evaluate the effectiveness of interventions on improving guideline-adherent cancer risk management (CRM) and family communication (FC) of genetic test results for individuals with a documented pathogenic/likely pathogenic (P/LP) variant, and FC of family cancer history for individuals with a variant of uncertain significance (VUS) in an inherited cancer gene.

Conditions

Inherited Cancer Syndrome, Prostate Cancer, Colorectal Cancer, Endometrial Cancer, Breast Cancer

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Study Overview

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Study Details

Study overview

The IMPACT Study seeks to refine and evaluate the effectiveness of interventions on improving guideline-adherent cancer risk management (CRM) and family communication (FC) of genetic test results for individuals with a documented pathogenic/likely pathogenic (P/LP) variant, and FC of family cancer history for individuals with a variant of uncertain significance (VUS) in an inherited cancer gene.

Improving Care After Inherited Cancer Testing (IMPACT) Study

Improving Care After Inherited Cancer Testing

Condition
Inherited Cancer Syndrome
Intervention / Treatment

-

Contacts and Locations

Nashville

Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, United States, 37212

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * English-speaking men and women aged 18 years or older
  • * Not adopted (i.e., have information about their biological relatives)
  • * Have access to internet and a computer, tablet, or smartphone
  • * Documented pathogenic/likely pathogenic variant in an inherited cancer gene that has CRM guidelines listed in the National Comprehensive Cancer Network (NCCN) Genetic/Familial Panel focused on Breast, Ovarian, and Pancreatic or Colorectal cancers
  • * Must meet at least one of the following criteria:
  • * Intervention A (GeneSHARE) criteria: Have at least one at-risk adult, living relative who either:
  • * has not been told about the genetic test result by the participant
  • * has not had their own genetic testing
  • * Intervention B (LivingLabReport) criteria: Are non-adherent (i.e., either undertreatment or overtreatment) to at least one of the current NCCN CRM guidelines or if currently adherent, require ongoing cancer screening
  • * English-speaking men and women aged 18 years or older
  • * Not adopted (i.e., have information about their biological relatives)
  • * Have access to internet and a computer, tablet, or smartphone
  • * Documented VUS in an inherited cancer gene

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Vanderbilt-Ingram Cancer Center,

Tuya Pal, MD, PRINCIPAL_INVESTIGATOR, Vanderbilt-Ingram Cancer Center

Study Record Dates

2028-12