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Fitness and Lung Function Among Survivors of Heart Transplant, Leukemia and Infant BPD Through Exercise

Description

This study aims to more accurately assess cardiac function, ventilation and exercise capacity in a non-invasive fashion, and to better characterize exercise intolerance in the setting of three populations of individuals with chronic diseases of childhood (acute lymphoblastic leukemia (ALL), chronic lung disease (CLD) of prematurity, and post-heart transplant (HT))

Conditions

Chronic Lung DiseaseChronic Obstructive Pulmonary DiseaseAcute Lymphoblastic LeukemiaHeart Transplant
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Related Conditions:

Chronic Lung DiseaseChronic Obstructive Pulmonary DiseaseAcute Lymphoblastic LeukemiaHeart Transplant

Study Overview

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Study Details

Study overview

This study aims to more accurately assess cardiac function, ventilation and exercise capacity in a non-invasive fashion, and to better characterize exercise intolerance in the setting of three populations of individuals with chronic diseases of childhood (acute lymphoblastic leukemia (ALL), chronic lung disease (CLD) of prematurity, and post-heart transplant (HT))

Fitness and Lung Function Among Survivors of Heart Transplant, Leukemia and Infant Bronchopulmonary Dysplasia (BPD, Also Known as Chronic Lung Disease of Prematurity) Through Exercise (FLASHLITE)

Fitness and Lung Function Among Survivors of Heart Transplant, Leukemia and Infant BPD Through Exercise

Condition
Chronic Lung Disease
Intervention / Treatment

-

Contacts and Locations

Minneapolis

Masonic Cancer Center, Minneapolis, Minnesota, United States, 55455

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Cases:
  • * Acute lymphoblastic leukemia survivor, OR living with chronic lung disease of prematurity, OR living with heart transplant
  • * 8-25 years old
  • * Height: ≥ 48 inches
  • * Ambulatory without assistance
  • * English speaking
  • * Normotensive (\<95th percentile for age; okay if managed with antihypertensive medication)
  • * SpO2 \>92%
  • * Not pregnant
  • * ALL survivor specific: must have completed therapy ≥ 3 months prior to study entry
  • * Controls
  • * 8-25 years old
  • * Height: ≥ 48 inches
  • * Ambulatory without assistance
  • * English speaking
  • * No history of arrhythmia or known cardiac dysfunction at baseline
  • * Normotensive (\<95th percentile for age; okay if managed with antihypertensive medication)
  • * SpO2 \>95%
  • * Not pregnant
  • * Cases:
  • * ALL specific: received cranial radiation, bone marrow transplant recipients
  • * Investigator or patient's primary physician deems the patient unsuitable for the study
  • * Controls:
  • * History of malignancy, CLD or HT or any other diagnosis which may reduce cardiorespiratory function
  • * Investigator deems the patient unsuitable for the study

Ages Eligible for Study

8 Years to 25 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Masonic Cancer Center, University of Minnesota,

Pianosi Paolo, MD, PRINCIPAL_INVESTIGATOR, Masonic Children's Hospital, University of Minnesota

Study Record Dates

2025-12-01