RECRUITING

Fitness and Lung Function Among Survivors of Heart Transplant, Leukemia and Infant BPD Through Exercise

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study aims to more accurately assess cardiac function, ventilation and exercise capacity in a non-invasive fashion, and to better characterize exercise intolerance in the setting of three populations of individuals with chronic diseases of childhood (acute lymphoblastic leukemia (ALL), chronic lung disease (CLD) of prematurity, and post-heart transplant (HT))

Official Title

Fitness and Lung Function Among Survivors of Heart Transplant, Leukemia and Infant Bronchopulmonary Dysplasia (BPD, Also Known as Chronic Lung Disease of Prematurity) Through Exercise (FLASHLITE)

Quick Facts

Study Start:2025-03-14
Study Completion:2025-12-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05025774

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:8 Years to 25 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Not specified
Standard Ages:CHILD, ADULT
Inclusion CriteriaExclusion Criteria
  1. * Cases:
  2. * Acute lymphoblastic leukemia survivor, OR living with chronic lung disease of prematurity, OR living with heart transplant
  3. * 8-25 years old
  4. * Height: ≥ 48 inches
  5. * Ambulatory without assistance
  6. * English speaking
  7. * Normotensive (\<95th percentile for age; okay if managed with antihypertensive medication)
  8. * SpO2 \>92%
  9. * Not pregnant
  10. * ALL survivor specific: must have completed therapy ≥ 3 months prior to study entry
  11. * Controls
  12. * 8-25 years old
  13. * Height: ≥ 48 inches
  14. * Ambulatory without assistance
  15. * English speaking
  16. * No history of arrhythmia or known cardiac dysfunction at baseline
  17. * Normotensive (\<95th percentile for age; okay if managed with antihypertensive medication)
  18. * SpO2 \>95%
  19. * Not pregnant
  1. * Cases:
  2. * ALL specific: received cranial radiation, bone marrow transplant recipients
  3. * Investigator or patient's primary physician deems the patient unsuitable for the study
  4. * Controls:
  5. * History of malignancy, CLD or HT or any other diagnosis which may reduce cardiorespiratory function
  6. * Investigator deems the patient unsuitable for the study

Contacts and Locations

Study Contact

Char Napurski, MPH, CCRP
CONTACT
612-626-2140
bake0257@umn.edu
Pianosi Paolo, MD
CONTACT
ppianosi@umn.edu

Principal Investigator

Pianosi Paolo, MD
PRINCIPAL_INVESTIGATOR
Masonic Children's Hospital, University of Minnesota

Study Locations (Sites)

Masonic Cancer Center
Minneapolis, Minnesota, 55455
United States

Collaborators and Investigators

Sponsor: Masonic Cancer Center, University of Minnesota

  • Pianosi Paolo, MD, PRINCIPAL_INVESTIGATOR, Masonic Children's Hospital, University of Minnesota

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-03-14
Study Completion Date2025-12-01

Study Record Updates

Study Start Date2025-03-14
Study Completion Date2025-12-01

Terms related to this study

Keywords Provided by Researchers

  • Quality of life
  • Lung function
  • Fitness
  • Exercise

Additional Relevant MeSH Terms

  • Chronic Lung Disease
  • Chronic Obstructive Pulmonary Disease
  • Acute Lymphoblastic Leukemia
  • Heart Transplant