RECRUITING

Immunological Effects of Vitamin D Replacement Among Black/African American Prostate Cancer Patients

Description

This early phase I is to find out how common vitamin D insufficiency is among African American patients with a history of prostate cancer that has not spread to other parts of the body (localized) or has spread to other places in the body (metastatic) and how vitamin D insufficiency affects the immune system. This study also aims to find out if replacing vitamin D results in normalization of the immune function. Information from this study may benefit prostate cancer patients by identifying vitamin D insufficiency which in several studies had been found to contribute to more aggressive prostate cancers.

Study Overview

Study Details

Study overview

This early phase I is to find out how common vitamin D insufficiency is among African American patients with a history of prostate cancer that has not spread to other parts of the body (localized) or has spread to other places in the body (metastatic) and how vitamin D insufficiency affects the immune system. This study also aims to find out if replacing vitamin D results in normalization of the immune function. Information from this study may benefit prostate cancer patients by identifying vitamin D insufficiency which in several studies had been found to contribute to more aggressive prostate cancers.

Differences in Immunological Effects of Vitamin D Replacement Among Black/African American (AA) Prostate Cancer Patients With Localized Versus Metastatic Disease

Immunological Effects of Vitamin D Replacement Among Black/African American Prostate Cancer Patients

Condition
Localized Prostate Carcinoma
Intervention / Treatment

-

Contacts and Locations

Scottsdale

Mayo Clinic in Arizona, Scottsdale, Arizona, United States, 85259

Jacksonville

Mayo Clinic in Florida, Jacksonville, Florida, United States, 32224-9980

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * African American males, age \>= 18 years
  • * Patients with a previous history of localized or metastatic or locally recurrent prostate cancer
  • * Patients with Vitamin D levels below 30 ng/mL
  • * Known hypersensitivity to vitamin D
  • * End stage renal failure on dialysis
  • * Liver cirrhosis
  • * Currently taking a vitamin D or multivitamin supplement, that has more than 400 IU/10mcg of vitamin D daily for the past month
  • * Legal inability or restricted legal ability. Medical or psychological conditions not allowing proper study completion or informed consent signature
  • * Chemotherapy or surgery or radiation within the last 3 weeks prior to blood collection
  • * History of hypercalcemia

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

MALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

Mayo Clinic,

Gerardo Colon-Otero, M.D., PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

2026-08-31