Immunological Effects of Vitamin D Replacement Among Black/African American Prostate Cancer Patients

Description

This early phase I is to find out how common vitamin D insufficiency is among African American patients with a history of prostate cancer that has not spread to other parts of the body (localized) or has spread to other places in the body (metastatic) and how vitamin D insufficiency affects the immune system. This study also aims to find out if replacing vitamin D results in normalization of the immune function. Information from this study may benefit prostate cancer patients by identifying vitamin D insufficiency which in several studies had been found to contribute to more aggressive prostate cancers.

Conditions

Localized Prostate Carcinoma, Stage IV Prostate Cancer AJCC v8

Study Overview

Study Details

Study overview

This early phase I is to find out how common vitamin D insufficiency is among African American patients with a history of prostate cancer that has not spread to other parts of the body (localized) or has spread to other places in the body (metastatic) and how vitamin D insufficiency affects the immune system. This study also aims to find out if replacing vitamin D results in normalization of the immune function. Information from this study may benefit prostate cancer patients by identifying vitamin D insufficiency which in several studies had been found to contribute to more aggressive prostate cancers.

Differences in Immunological Effects of Vitamin D Replacement Among Black/African American (AA) Prostate Cancer Patients With Localized Versus Metastatic Disease

Immunological Effects of Vitamin D Replacement Among Black/African American Prostate Cancer Patients

Condition
Localized Prostate Carcinoma
Intervention / Treatment

-

Contacts and Locations

Scottsdale

Mayo Clinic in Arizona, Scottsdale, Arizona, United States, 85259

Jacksonville

Mayo Clinic in Florida, Jacksonville, Florida, United States, 32224-9980

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * African American males, age \>= 18 years
  • * Patients with a previous history of localized or metastatic or locally recurrent prostate cancer
  • * Patients with Vitamin D levels below 30 ng/mL
  • * Known hypersensitivity to vitamin D
  • * End stage renal failure on dialysis
  • * Liver cirrhosis
  • * Currently taking a vitamin D or multivitamin supplement, that has more than 400 IU/10mcg of vitamin D daily for the past month
  • * Legal inability or restricted legal ability. Medical or psychological conditions not allowing proper study completion or informed consent signature
  • * Chemotherapy or surgery or radiation within the last 3 weeks prior to blood collection
  • * History of hypercalcemia

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

MALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

Mayo Clinic,

Gerardo Colon-Otero, M.D., PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

2026-08-31