RECRUITING

CYP2C19 Variants and Limonene Metabolism

Conditions

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The investigators will examine whether a non-invasive screening tool for CYP2C19 genetic variants can be developed by measuring limonene metabolism.

Official Title

Functional Consequences of CYP2C19 Variants on Limonene Metabolism in Humans

Quick Facts

Study Start:2021-10-30

Study Completion:2024-12

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT05078723

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 45 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT

Inclusion Criteria	Exclusion Criteria
* Age range: Greater than 18 years and less than 45 years. * Gender: Male or Female * Ethnicities: East Asian	* Pregnant and/or Breastfeeding * previous allergic reaction to limonene, citrus fruits, bovine gelatin, glycerin * past medical history of cerebrovascular or cardiovascular disease * veganism * history of chest pain or shortness of breath in the past month * certain medications that are CYP2C19 substrates or CYP2C19 inhibitors * Non-East Asian descent * age less than 18 y.o or age greater than 45 y.o

Inclusion Criteria

Exclusion Criteria

* Age range: Greater than 18 years and less than 45 years.
* Gender: Male or Female
* Ethnicities: East Asian

* Pregnant and/or Breastfeeding
* previous allergic reaction to limonene, citrus fruits, bovine gelatin, glycerin
* past medical history of cerebrovascular or cardiovascular disease
* veganism
* history of chest pain or shortness of breath in the past month
* certain medications that are CYP2C19 substrates or CYP2C19 inhibitors
* Non-East Asian descent
* age less than 18 y.o or age greater than 45 y.o

Contacts and Locations

Study Contact

Eric Gross, MD/PhD

CONTACT

(650)721-4521

ergross@stanford.edu

Study Locations (Sites)

Stanford School of Medicine

Stanford, California, 94305

United States

Collaborators and Investigators

Sponsor: Stanford University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-10-30

Study Completion Date2024-12

Study Record Updates

Study Start Date2021-10-30

Study Completion Date2024-12

Terms related to this study

Additional Relevant MeSH Terms

CYP2C19 Genetic Variants