RECRUITING

Cerebellar Stimulation for Aphasia Rehabilitation

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Conditions

Stroke

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The optimal site of neuromodulation for post-stroke aphasia has yet to be established. This study will investigate whether multiple sessions of cerebellar transcranial direct current stimulation (tDCS) boosts language therapy in helping people recover from aphasia as well as predict who is likely to respond to cerebellar tDCS.

Official Title

Cerebellar Stimulation for Aphasia Rehabilitation

Quick Facts

Study Start:2021-10-25
Study Completion:2028-04-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05093673

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 99 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Chronic ischemic or hemorrhagic left hemisphere stroke
  2. * Fluent speaker of English by self-report
  3. * Age 18 or older
  4. * 6 months post onset of stroke
  5. * Diagnosis of aphasia and naming impairment using the Western Aphasia Battery-Revised
  1. * Lesion in the right cerebellum
  2. * Previous neurological disorder (other than stroke) affecting the brain, or any other neurodegenerative disorder or psychiatric disorder
  3. * Seizures during the previous 6 months
  4. * Uncorrected visual loss or hearing loss by self-report
  5. * Use of medications that lower the seizure threshold (e.g., methylphenidate)
  6. * Use of N-methyl-D-aspartate (NMDA) antagonists (e.g., memantine)
  7. * \>80% correct response on the Philadelphia Naming Testing at baseline
  8. * History of brain surgery or any metal in the head
  9. * Severely impaired auditory comprehension (lower than 2 on the Comprehension subscore on the Western Aphasia Battery-Revised)
  10. * Severely limited verbal output (lower than 2 on the Spontaneous Speech rating scale on the Western Aphasia Battery-Revised)
  11. * Individuals with severe claustrophobia, cardiac pacemakers or ferromagnetic implants, and pregnant women will be excluded from the MRI portion of the study.

Contacts and Locations

Study Contact

Rajani Sebastian, PhD
CONTACT
410-502-5012
rsebast3@jhmi.edu
Becky Lammers, MS
CONTACT
410-502-2445
blammer2@jh.edu

Principal Investigator

Rajani Sebastian, PhD
PRINCIPAL_INVESTIGATOR
Johns Hopkins University

Study Locations (Sites)

Johns Hopkins Hospital
Baltimore, Maryland, 21287
United States

Collaborators and Investigators

Sponsor: Johns Hopkins University

  • Rajani Sebastian, PhD, PRINCIPAL_INVESTIGATOR, Johns Hopkins University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-10-25
Study Completion Date2028-04-01

Study Record Updates

Study Start Date2021-10-25
Study Completion Date2028-04-01

Terms related to this study

Additional Relevant MeSH Terms

  • Stroke