Cerebellar Stimulation for Aphasia Rehabilitation

Description

The optimal site of neuromodulation for post-stroke aphasia has yet to be established. This study will investigate whether multiple sessions of cerebellar transcranial direct current stimulation (tDCS) boosts language therapy in helping people recover from aphasia as well as predict who is likely to respond to cerebellar tDCS.

Conditions

Stroke

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Study Overview

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Study Details

Study overview

The optimal site of neuromodulation for post-stroke aphasia has yet to be established. This study will investigate whether multiple sessions of cerebellar transcranial direct current stimulation (tDCS) boosts language therapy in helping people recover from aphasia as well as predict who is likely to respond to cerebellar tDCS.

Cerebellar Stimulation for Aphasia Rehabilitation

Cerebellar Stimulation for Aphasia Rehabilitation

Condition
Stroke
Intervention / Treatment

-

Contacts and Locations

Baltimore

Johns Hopkins Hospital, Baltimore, Maryland, United States, 21287

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Chronic ischemic or hemorrhagic left hemisphere stroke
  • * Fluent speaker of English by self-report
  • * Age 18 or older
  • * 6 months post onset of stroke
  • * Diagnosis of aphasia and naming impairment using the Western Aphasia Battery-Revised
  • * Lesion in the right cerebellum
  • * Previous neurological disorder (other than stroke) affecting the brain, or any other neurodegenerative disorder or psychiatric disorder
  • * Seizures during the previous 6 months
  • * Uncorrected visual loss or hearing loss by self-report
  • * Use of medications that lower the seizure threshold (e.g., methylphenidate)
  • * Use of N-methyl-D-aspartate (NMDA) antagonists (e.g., memantine)
  • * \>80% correct response on the Philadelphia Naming Testing at baseline
  • * History of brain surgery or any metal in the head
  • * Severely impaired auditory comprehension (lower than 2 on the Comprehension subscore on the Western Aphasia Battery-Revised)
  • * Severely limited verbal output (lower than 2 on the Spontaneous Speech rating scale on the Western Aphasia Battery-Revised)
  • * Individuals with severe claustrophobia, cardiac pacemakers or ferromagnetic implants, and pregnant women will be excluded from the MRI portion of the study.

Ages Eligible for Study

18 Years to 99 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Johns Hopkins University,

Rajani Sebastian, PhD, PRINCIPAL_INVESTIGATOR, Johns Hopkins University

Study Record Dates

2028-04-01