RECRUITING

Autologous Mesenchymal Stromal Cells and Islet Co-transplantation in TP-IAT

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is a clinical trial for chronic pancreatitis (CP) patients undergoing total pancreatectomy with islet autotransplantation (TP-IAT). Participants will be randomized to either bone marrow-derived mesenchymal stem cells (MSCs) or control with the standard of care. Participants will be followed for one-year post-transplant.

Official Title

Autologous Mesenchymal Stromal Cells and Islet Co-transplantation to Enhance Islet Survival and Function in Chronic Pancreatitis Patients Undergo Total Pancreatectomy and Islet Autotransplantation

Quick Facts

Study Start:2021-12-01
Study Completion:2026-06-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05095532

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Diagnosis of CP and scheduled for TP-IAT;
  2. * ≥18 years old;
  3. * Diabetes with HbA1c \<12%.
  1. * Patients who are under immunosuppression;
  2. * Pregnant and breastfeeding women.
  3. * Patients who have liver damage based on ALT, AST, and total bilirubin levels (\>3 times normal levels);

Contacts and Locations

Study Contact

Leah Benn, MPH
CONTACT
843-792-2813
bennle@musc.edu
Kelsey Cook
CONTACT
843 876 0420
conder@musc.edu

Principal Investigator

Charlton Strange, M.D
STUDY_DIRECTOR
Medical University of South Carolina
Katherine Morgan, M.D
STUDY_DIRECTOR
Medical University of South Carolina
Hongjun Wang
PRINCIPAL_INVESTIGATOR
Medical University of South Carolina

Study Locations (Sites)

Medical University of South Carolina
Charleston, South Carolina, 29425
United States

Collaborators and Investigators

Sponsor: Medical University of South Carolina

  • Charlton Strange, M.D, STUDY_DIRECTOR, Medical University of South Carolina
  • Katherine Morgan, M.D, STUDY_DIRECTOR, Medical University of South Carolina
  • Hongjun Wang, PRINCIPAL_INVESTIGATOR, Medical University of South Carolina

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-12-01
Study Completion Date2026-06-30

Study Record Updates

Study Start Date2021-12-01
Study Completion Date2026-06-30

Terms related to this study

Keywords Provided by Researchers

  • Total Pancreatectomy
  • TP-IAT

Additional Relevant MeSH Terms

  • Chronic Pancreatitis
  • Mesenchymal Stem Cells