Autologous Mesenchymal Stromal Cells and Islet Co-transplantation in TP-IAT

Description

This is a clinical trial for chronic pancreatitis (CP) patients undergoing total pancreatectomy with islet autotransplantation (TP-IAT). Participants will be randomized to either bone marrow-derived mesenchymal stem cells (MSCs) or control with the standard of care. Participants will be followed for one-year post-transplant.

Conditions

Chronic Pancreatitis, Mesenchymal Stem Cells

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Study Overview

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Study Details

Study overview

This is a clinical trial for chronic pancreatitis (CP) patients undergoing total pancreatectomy with islet autotransplantation (TP-IAT). Participants will be randomized to either bone marrow-derived mesenchymal stem cells (MSCs) or control with the standard of care. Participants will be followed for one-year post-transplant.

Autologous Mesenchymal Stromal Cells and Islet Co-transplantation to Enhance Islet Survival and Function in Chronic Pancreatitis Patients Undergo Total Pancreatectomy and Islet Autotransplantation

Autologous Mesenchymal Stromal Cells and Islet Co-transplantation in TP-IAT

Condition
Chronic Pancreatitis
Intervention / Treatment

-

Contacts and Locations

Charleston

Medical University of South Carolina, Charleston, South Carolina, United States, 29425

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Diagnosis of CP and scheduled for TP-IAT;
  • * ≥18 years old;
  • * Diabetes with HbA1c \<12%.
  • * Patients who are under immunosuppression;
  • * Pregnant and breastfeeding women.
  • * Patients who have liver damage based on ALT, AST, and total bilirubin levels (\>3 times normal levels);

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Medical University of South Carolina,

Charlton Strange, M.D, STUDY_DIRECTOR, Medical University of South Carolina

Katherine Morgan, M.D, STUDY_DIRECTOR, Medical University of South Carolina

Hongjun Wang, PRINCIPAL_INVESTIGATOR, Medical University of South Carolina

Study Record Dates

2026-06-30