ACTIVE_NOT_RECRUITING

Histamine as a Molecular Transducer of Adaptation to Exercise

Conditions

Postexercise Hypotension Histamine Mast cell Exercise

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study is investigating the role of histamine in generating adaptation to exercise

Official Title

Histamine as a Molecular Transducer of Adaptation to Exercise

Quick Facts

Study Start:2021-07-28

Study Completion:2027-03-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:ACTIVE_NOT_RECRUITING

Study ID

NCT05206227

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 40 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT

Inclusion Criteria	Exclusion Criteria
* Age 18 -40	* Systolic ≥ 120 * Diastolic ≥ 80 * Body mass index (BMI) ˃ 28 kg/m2 * Prior diagnosis of cardiovascular disease, diabetes, autonomic disorders, or asthma * Smoking or nicotine use * Ongoing medical therapy (other than birth control) * Ongoing use of over-the-counter or prescription antihistamines * Allergies or hypersensitivities to drugs, local anesthetics, skin disinfectants, adhesives, or latex * Pregnant, breastfeeding subjects, or planning to become pregnant in the next 12 months * Mobility restrictions that interfere with physical activity * High physical activity based on International Physical Activity Questionaire (IPAQ1) * Non-English speaking

Inclusion Criteria

Exclusion Criteria

* Age 18 -40

* Systolic ≥ 120
* Diastolic ≥ 80
* Body mass index (BMI) ˃ 28 kg/m2
* Prior diagnosis of cardiovascular disease, diabetes, autonomic disorders, or asthma
* Smoking or nicotine use
* Ongoing medical therapy (other than birth control)
* Ongoing use of over-the-counter or prescription antihistamines
* Allergies or hypersensitivities to drugs, local anesthetics, skin disinfectants, adhesives, or latex
* Pregnant, breastfeeding subjects, or planning to become pregnant in the next 12 months
* Mobility restrictions that interfere with physical activity
* High physical activity based on International Physical Activity Questionaire (IPAQ1)
* Non-English speaking

Contacts and Locations

Principal Investigator

John R Halliwill, PhD

PRINCIPAL_INVESTIGATOR

University of Oregon

Study Locations (Sites)

University of Oregon

Eugene, Oregon, 97403

United States

Collaborators and Investigators

Sponsor: University of Oregon

John R Halliwill, PhD, PRINCIPAL_INVESTIGATOR, University of Oregon

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-07-28

Study Completion Date2027-03-31

Study Record Updates

Study Start Date2021-07-28

Study Completion Date2027-03-31

Terms related to this study

Keywords Provided by Researchers

Histamine
Mast cell
Exercise

Additional Relevant MeSH Terms

Postexercise Hypotension