RECRUITING

Immune Responses to Gluten

Description

This is a study of immune responses after eating gluten powder in people with celiac disease and healthy controls.

Conditions

Celiac DiseaseMalabsorption SyndromesDigestive System DiseaseIntestinal DiseaseGastrointestinal DiseasesGluten SensitivityCeliac Disease in Children
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Related Conditions:

Celiac DiseaseMalabsorption SyndromesDigestive System DiseaseIntestinal DiseaseGastrointestinal DiseasesGluten SensitivityCeliac Disease in Children

Study Overview

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Study Details

Study overview

This is a study of immune responses after eating gluten powder in people with celiac disease and healthy controls.

Changes in Serum IL-2 Levels Following a Single Oral Dose of Gluten

Immune Responses to Gluten

Condition
Celiac Disease
Intervention / Treatment

-

Contacts and Locations

Aurora

Children's Hospital Colorado, Aurora, Colorado, United States, 80045

Boston

Boston Children's Hospital, Boston, Massachusetts, United States, 02115

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. On a gluten-free diet for ≥ 4 weeks
  • 2. Willing to consume gluten for research
  • 3. For the celiac disease arm, diagnosis confirmed by serology and/or histology
  • 1. Pregnancy
  • 2. Wheat allergy
  • 3. Type 1 diabetes
  • 4. BMI z-score \< -2
  • 5. History of more than minimal symptoms following gluten exposure on a gluten-free diet
  • 6. Comorbid condition that in the opinion of the investigator would interfere with study participation or would confound study results

Ages Eligible for Study

2 Years to 101 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Boston Children's Hospital,

Jocelyn A Silvester, MD, PhD, PRINCIPAL_INVESTIGATOR, Boston Children's Hospital

Study Record Dates

2029-09-30