Immune Responses to Gluten

Description

This is a study of immune responses after eating gluten powder in people with celiac disease and healthy controls.

Conditions

Celiac Disease, Malabsorption Syndromes, Digestive System Disease, Intestinal Disease, Gastrointestinal Diseases, Gluten Sensitivity, Celiac Disease in Children

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Study Overview

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Study Details

Study overview

This is a study of immune responses after eating gluten powder in people with celiac disease and healthy controls.

Changes in Serum IL-2 Levels Following a Single Oral Dose of Gluten

Immune Responses to Gluten

Condition
Celiac Disease
Intervention / Treatment

-

Contacts and Locations

Aurora

Children's Hospital Colorado, Aurora, Colorado, United States, 80045

Boston

Boston Children's Hospital, Boston, Massachusetts, United States, 02115

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. On a gluten-free diet for ≥ 4 weeks
  • 2. Willing to consume gluten for research
  • 3. For the celiac disease arm, diagnosis confirmed by serology and/or histology
  • 1. Pregnancy
  • 2. Wheat allergy
  • 3. Type 1 diabetes
  • 4. BMI z-score \< -2
  • 5. History of more than minimal symptoms following gluten exposure on a gluten-free diet
  • 6. Comorbid condition that in the opinion of the investigator would interfere with study participation or would confound study results

Ages Eligible for Study

2 Years to 101 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Boston Children's Hospital,

Jocelyn A Silvester, MD, PhD, PRINCIPAL_INVESTIGATOR, Boston Children's Hospital

Study Record Dates

2029-09-30