RECRUITING

ERP to Improve Functioning in Veterans With OCD

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Obsessive compulsive disorder (OCD) is a debilitating psychiatric illness impacting work, social, and family functioning. Exposure and Response Prevention (ERP) is the sole evidence-based psychotherapy for OCD; however, no randomized controlled trials (RCTs) have examined the effectiveness of ERP among Veterans or individuals with both OCD and posttraumatic stress disorder (PTSD). This 4-year Hybrid Type I trial will compare outcomes of ERP to those of a control condition among Veterans with OCD. Primary and secondary aims will examine whether Veterans' functioning, quality of life, and OCD symptoms differ between the ERP and control in the full sample of Veterans with OCD, and in the half of the sample with both OCD and PTSD. The tertiary aim is to conduct a mixed-methods formative evaluation of the implementation potential of ERP in VA mental health settings.

Official Title

Exposure and Response Prevention to Improve Functioning in Veterans With Obsessive Compulsive Disorder

Quick Facts

Study Start:2022-10-03
Study Completion:2026-05-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05240924

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Veterans having a primary diagnosis of Obsessive Compulsive Disorder (OCD)(50% of sample) and comorbid OCD and Post-traumatic stress disorder (PTSD) (50% of sample) who are receiving care from the Michael E. DeBakey VA Medical Center (MEDVAMC) in Houston, TX; the Ralph H. Johnson VA Medical Center in Charleston, SC; and the VISN 20 Clinical Resource Hub which provides telehealth services to Washington, Oregon, and Alaska.
  2. * Willingness to participate in Exposure and Response Prevention(ERP)
  1. * Significant cognitive impairment or conditions that threaten safety (current psychosis, mania, imminent suicidality including plan or intent, and treatment-interfering moderate to severe substance use).
  2. * Potential participants taking psychotropic medications must be on a stable dose of these medications for at least 6 weeks prior to study enrollment.

Contacts and Locations

Study Contact

Matthew G Escamilla, BS
CONTACT
(713) 440-4461
matthew.escamilla@va.gov
Terri L Fletcher, PhD
CONTACT
(713) 440-4400
Terri.Fletcher@va.gov

Principal Investigator

Terri L. Fletcher, PhD
PRINCIPAL_INVESTIGATOR
Michael E. DeBakey VA Medical Center, Houston, TX

Study Locations (Sites)

VA Roseburg Healthcare System, Roseburg, OR
Roseburg, Oregon, 97471
United States
VA Southern Oregon Rehabilitation Center and Clinics, White City, OR
White City, Oregon, 97503
United States
Ralph H. Johnson VA Medical Center, Charleston, SC
Charleston, South Carolina, 29401-5703
United States
Michael E. DeBakey VA Medical Center, Houston, TX
Houston, Texas, 77030-4211
United States
Spokane VA Medical Center, Spokane, WA
Spokane, Washington, 99205-6185
United States
Jonathan M. Wainwright Memorial VA Medical Center, Walla Walla, WA
Walla Walla, Washington, 99362-3975
United States

Collaborators and Investigators

Sponsor: VA Office of Research and Development

  • Terri L. Fletcher, PhD, PRINCIPAL_INVESTIGATOR, Michael E. DeBakey VA Medical Center, Houston, TX

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-10-03
Study Completion Date2026-05-31

Study Record Updates

Study Start Date2022-10-03
Study Completion Date2026-05-31

Terms related to this study

Keywords Provided by Researchers

  • Obsessive Compulsive Disorder
  • OCD
  • Post-Traumatic Stress Disorder
  • PTSD
  • Worry
  • Compulsion
  • Stress

Additional Relevant MeSH Terms

  • Obsessive Compulsive Disorder (OCD)
  • Comorbid Post-Traumatic Stress Disorder and OCD