ERP to Improve Functioning in Veterans With OCD

Description

Obsessive compulsive disorder (OCD) is a debilitating psychiatric illness impacting work, social, and family functioning. Exposure and Response Prevention (ERP) is the sole evidence-based psychotherapy for OCD; however, no randomized controlled trials (RCTs) have examined the effectiveness of ERP among Veterans or individuals with both OCD and posttraumatic stress disorder (PTSD). This 4-year Hybrid Type I trial will compare outcomes of ERP to those of a control condition among Veterans with OCD. Primary and secondary aims will examine whether Veterans' functioning, quality of life, and OCD symptoms differ between the ERP and control in the full sample of Veterans with OCD, and in the half of the sample with both OCD and PTSD. The tertiary aim is to conduct a mixed-methods formative evaluation of the implementation potential of ERP in VA mental health settings.

Conditions

Obsessive Compulsive Disorder (OCD), Comorbid Post-Traumatic Stress Disorder and OCD

Talk to us

Study Overview

On this page

Study Details

Study overview

Obsessive compulsive disorder (OCD) is a debilitating psychiatric illness impacting work, social, and family functioning. Exposure and Response Prevention (ERP) is the sole evidence-based psychotherapy for OCD; however, no randomized controlled trials (RCTs) have examined the effectiveness of ERP among Veterans or individuals with both OCD and posttraumatic stress disorder (PTSD). This 4-year Hybrid Type I trial will compare outcomes of ERP to those of a control condition among Veterans with OCD. Primary and secondary aims will examine whether Veterans' functioning, quality of life, and OCD symptoms differ between the ERP and control in the full sample of Veterans with OCD, and in the half of the sample with both OCD and PTSD. The tertiary aim is to conduct a mixed-methods formative evaluation of the implementation potential of ERP in VA mental health settings.

Exposure and Response Prevention to Improve Functioning in Veterans With Obsessive Compulsive Disorder

ERP to Improve Functioning in Veterans With OCD

Condition
Obsessive Compulsive Disorder (OCD)
Intervention / Treatment

-

Contacts and Locations

Roseburg

VA Roseburg Healthcare System, Roseburg, OR, Roseburg, Oregon, United States, 97471

White City

VA Southern Oregon Rehabilitation Center and Clinics, White City, OR, White City, Oregon, United States, 97503

Charleston

Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston, South Carolina, United States, 29401-5703

Houston

Michael E. DeBakey VA Medical Center, Houston, TX, Houston, Texas, United States, 77030-4211

Spokane

Spokane VA Medical Center, Spokane, WA, Spokane, Washington, United States, 99205-6185

Walla Walla

Jonathan M. Wainwright Memorial VA Medical Center, Walla Walla, WA, Walla Walla, Washington, United States, 99362-3975

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Veterans having a primary diagnosis of Obsessive Compulsive Disorder (OCD)(50% of sample) and comorbid OCD and Post-traumatic stress disorder (PTSD) (50% of sample) who are receiving care from the Michael E. DeBakey VA Medical Center (MEDVAMC) in Houston, TX; the Ralph H. Johnson VA Medical Center in Charleston, SC; and the VISN 20 Clinical Resource Hub which provides telehealth services to Washington, Oregon, and Alaska.
  • * Willingness to participate in Exposure and Response Prevention(ERP)
  • * Significant cognitive impairment or conditions that threaten safety (current psychosis, mania, imminent suicidality including plan or intent, and treatment-interfering moderate to severe substance use).
  • * Potential participants taking psychotropic medications must be on a stable dose of these medications for at least 6 weeks prior to study enrollment.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

VA Office of Research and Development,

Terri L. Fletcher, PhD, PRINCIPAL_INVESTIGATOR, Michael E. DeBakey VA Medical Center, Houston, TX

Study Record Dates

2026-05-31