RECRUITING

Valacyclovir in Pain Management of Acute Apical Abscesses

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Conditions

Acute Apical AbscessPain, Acute

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The Virus in Endodontics (VE) phase I pilot study for preoperative pain will be analyzed and adjusted for the Phase II clinical trial. The Phase II clinical trial on preoperative pain, postoperative pain, and clinical healing will involve 250 patients. Patients will be recruited from the same pool of participants as the Phase II clinical trial. Preoperative cone beam computed tomography (CBCT) scans will be taken as well as three and six month postoperative CBCT scans. The secondary outcomes form the Phase II randomized clinical trial will be clinical success and visible radiographic healing determined by CBCT images.

Official Title

Role of Herpesviruses as a Causative Factor in Acute Apical Abscess

Quick Facts

Study Start:2023-05-01
Study Completion:2024-11-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05266040

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Patient must be ≥ 18-year-old
  2. * Patient must be systemically healthy; American Society of Anesthesiologists (ASA) Class I or II
  3. * Patient must exhibit clinical evidence of pulp necrosis and acute apical abscess
  4. * Patient must present with radiographic
  5. * signs of apical disease either by
  6. * periapical radiography or cone-beam
  7. * computed tomography
  8. * Patient consented to receive conventional pulpal debridement, incision and drainage at the end of the study
  9. * Persistent pain of moderate or higher level (\>4) was the main inclusion criterion. Pain assessed as follows: 0 defined as no pain, 1-3 as mild pain, 4-6 as moderate pain, and 7-10 as severe pain
  1. * Smokers (more than 10 cigarettes per day)
  2. * External or internal tooth resorption
  3. * Marginal periodontitis
  4. * Pregnant or nursing mothers (hormonal factors may influence the periapical condition)
  5. * Documented allergic or adverse reactions to amoxicillin or valacyclovir
  6. * Teeth with unusual anatomy or inaccurate clinical diagnosis on the day of treatment (i.e., partially necrotic pulp)
  7. * Patients currently taking antibiotics or antiviral medications

Contacts and Locations

Study Contact

Mike Sabeti, DDS
CONTACT
415-476-0822
Mike.Sabeti@ucsf.edu

Principal Investigator

Mike Sabeti, DDS
PRINCIPAL_INVESTIGATOR
University of California, San Francisco

Study Locations (Sites)

UCSF Dental
San Francisco, California, 94143
United States

Collaborators and Investigators

Sponsor: University of California, San Francisco

  • Mike Sabeti, DDS, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-05-01
Study Completion Date2024-11-30

Study Record Updates

Study Start Date2023-05-01
Study Completion Date2024-11-30

Terms related to this study

Additional Relevant MeSH Terms

  • Acute Apical Abscess
  • Pain, Acute