Valacyclovir in Pain Management of Acute Apical Abscesses

Description

The Virus in Endodontics (VE) phase I pilot study for preoperative pain will be analyzed and adjusted for the Phase II clinical trial. The Phase II clinical trial on preoperative pain, postoperative pain, and clinical healing will involve 250 patients. Patients will be recruited from the same pool of participants as the Phase II clinical trial. Preoperative cone beam computed tomography (CBCT) scans will be taken as well as three and six month postoperative CBCT scans. The secondary outcomes form the Phase II randomized clinical trial will be clinical success and visible radiographic healing determined by CBCT images.

Conditions

Acute Apical Abscess, Pain, Acute

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Study Overview

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Study Details

Study overview

The Virus in Endodontics (VE) phase I pilot study for preoperative pain will be analyzed and adjusted for the Phase II clinical trial. The Phase II clinical trial on preoperative pain, postoperative pain, and clinical healing will involve 250 patients. Patients will be recruited from the same pool of participants as the Phase II clinical trial. Preoperative cone beam computed tomography (CBCT) scans will be taken as well as three and six month postoperative CBCT scans. The secondary outcomes form the Phase II randomized clinical trial will be clinical success and visible radiographic healing determined by CBCT images.

Role of Herpesviruses as a Causative Factor in Acute Apical Abscess

Valacyclovir in Pain Management of Acute Apical Abscesses

Condition
Acute Apical Abscess
Intervention / Treatment

-

Contacts and Locations

San Francisco

UCSF Dental, San Francisco, California, United States, 94143

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patient must be ≥ 18-year-old
  • * Patient must be systemically healthy; American Society of Anesthesiologists (ASA) Class I or II
  • * Patient must exhibit clinical evidence of pulp necrosis and acute apical abscess
  • * Patient must present with radiographic
  • * signs of apical disease either by
  • * periapical radiography or cone-beam
  • * computed tomography
  • * Patient consented to receive conventional pulpal debridement, incision and drainage at the end of the study
  • * Persistent pain of moderate or higher level (\>4) was the main inclusion criterion. Pain assessed as follows: 0 defined as no pain, 1-3 as mild pain, 4-6 as moderate pain, and 7-10 as severe pain
  • * Smokers (more than 10 cigarettes per day)
  • * External or internal tooth resorption
  • * Marginal periodontitis
  • * Pregnant or nursing mothers (hormonal factors may influence the periapical condition)
  • * Documented allergic or adverse reactions to amoxicillin or valacyclovir
  • * Teeth with unusual anatomy or inaccurate clinical diagnosis on the day of treatment (i.e., partially necrotic pulp)
  • * Patients currently taking antibiotics or antiviral medications

Ages Eligible for Study

18 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of California, San Francisco,

Mike Sabeti, DDS, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

2024-11-30