COMPLETED

MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

To examine vascular reactivity and inflammatory biomarkers via quantitative magnetic resonance imaging (MRI) and blood serum, respectively, in a crossover study where active vapers (electronic cigarette users) and smokers will undergo three separate acute exposure-episodes of electronic cigarette +/- nicotine and tobacco-cig. The MRI exams and blood draws will be performed pre- and post-exposure. The results will be compared against baseline values derived from a group of non-smokers/non-vapers, who will also undergo a blood draw and MRI.

Official Title

MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers

Quick Facts

Study Start:2022-06-07
Study Completion:2025-11-28
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT05271578

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 45 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * BMI: 18.5 to 30
  2. * Current users of electronic cigarettes or tobacco cigarettes with a use history of six months or greater.
  1. * Cancer
  2. * HIV
  3. * Mental illness in which the participant is not of proper cognizance
  4. * Overt cardio- or neurovascular disease (prior heart attack, stroke, transient ischemic attacks)
  5. * Serious arrhythmias
  6. * Bronchospastic disease
  7. * Upper respiratory tract infection within the past six weeks
  8. * Medication affecting vascular function
  9. * Antibiotics
  10. * Magnetic resonance imaging contraindications (metallic implants/intraocular foreign bodies, claustrophobia, cardiac/cochlear implantable electronic devices, etc.)

Contacts and Locations

Principal Investigator

Felix W Wehrli, PhD
PRINCIPAL_INVESTIGATOR
University of Pennsylvania

Study Locations (Sites)

University of Pennsylvania
Philadelphia, Pennsylvania, 19104
United States

Collaborators and Investigators

Sponsor: University of Pennsylvania

  • Felix W Wehrli, PhD, PRINCIPAL_INVESTIGATOR, University of Pennsylvania

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-06-07
Study Completion Date2025-11-28

Study Record Updates

Study Start Date2022-06-07
Study Completion Date2025-11-28

Terms related to this study

Keywords Provided by Researchers

  • Magnetic Resonance Imaging
  • Electronic Cigarettes
  • Endothelial Dysfunction
  • Nicotine
  • Inflammation

Additional Relevant MeSH Terms

  • Vascular Reactivity
  • Serum Biomarkers