MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers

Description

To examine vascular reactivity and inflammatory biomarkers via quantitative magnetic resonance imaging (MRI) and blood serum, respectively, in a crossover study where active vapers (electronic cigarette users) and smokers will undergo three separate acute exposure-episodes of electronic cigarette +/- nicotine and tobacco-cig. The MRI exams and blood draws will be performed pre- and post-exposure. The results will be compared against baseline values derived from a group of non-smokers/non-vapers, who will also undergo a blood draw and MRI.

Conditions

Vascular Reactivity, Serum Biomarkers

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Study Overview

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Study Details

Study overview

To examine vascular reactivity and inflammatory biomarkers via quantitative magnetic resonance imaging (MRI) and blood serum, respectively, in a crossover study where active vapers (electronic cigarette users) and smokers will undergo three separate acute exposure-episodes of electronic cigarette +/- nicotine and tobacco-cig. The MRI exams and blood draws will be performed pre- and post-exposure. The results will be compared against baseline values derived from a group of non-smokers/non-vapers, who will also undergo a blood draw and MRI.

MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers

MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers

Condition
Vascular Reactivity
Intervention / Treatment

-

Contacts and Locations

Philadelphia

University of Pennsylvania, Philadelphia, Pennsylvania, United States, 19104

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * BMI: 18.5 to 30
  • * Current users of electronic cigarettes or tobacco cigarettes with a use history of six months or greater.
  • * Cancer
  • * HIV
  • * Mental illness in which the participant is not of proper cognizance
  • * Overt cardio- or neurovascular disease (prior heart attack, stroke, transient ischemic attacks)
  • * Serious arrhythmias
  • * Bronchospastic disease
  • * Upper respiratory tract infection within the past six weeks
  • * Medication affecting vascular function
  • * Antibiotics
  • * Magnetic resonance imaging contraindications (metallic implants/intraocular foreign bodies, claustrophobia, cardiac/cochlear implantable electronic devices, etc.)

Ages Eligible for Study

18 Years to 45 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Pennsylvania,

Felix W Wehrli, PhD, PRINCIPAL_INVESTIGATOR, University of Pennsylvania

Study Record Dates

2025-08-31