RECRUITING

Peri-operative Oral Pain Control Following Buccal Graft Urethroplasty

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Patients undergoing buccal urethroplasty will often have significant post-operative oral pain from the graft site. Various graft harvest techniques and methods for post-harvest hemostasis including graft site closure have been explored. Despite the frequency of this clinical scenario there is no established best practice for peri-operative pain management in this patient population. In addition to traditional post operative pain control, groups have sought various peri-operative anesthetic regimens to improve post operative pain. This has led recently to the description of various regional blocks including buccal and periorbital blocks for peri-operative local anesthetic. No study has looked at superiority of regional pain management in this patient population. This study will aim to assess three established anesthetic protocols for oral pain control in a blinded, randomized controlled trial. Hypothesis: Patients who have buccal block will have lower post op pain without any increase adverse oral outcomes.

Official Title

Peri-operative Oral Pain Control Following Buccal Graft Urethroplasty: Randomized Control Trial of Harvest Site Anesthetic

Quick Facts

Study Start:2022-02-15
Study Completion:2026-03-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05300685

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:MALE
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Men, age 18 or older
  2. * Undergoing anterior urethroplasty with buccal grafting
  3. * Able to consent
  1. * Taking chronic opiates for pain
  2. * Diagnosis of chronic pain
  3. * Prior buccal urethroplasty
  4. * Vulnerable population (e.g. prisoner)
  5. * Renal dysfunction or allergy preventing NSAID use
  6. * Liver dysfunction or allergy preventing Tylenol use
  7. * Medical allergy to local anesthetic
  8. * Medical allergy to Peridex/Magic Mouthwash
  9. * NYHA Class III/IV
  10. * Hematologic condition that excludes patient from surgery
  11. * Post-operative complication resulting in inpatient stay
  12. * Anesthetic complication
  13. * No buccal site surgical complication

Contacts and Locations

Study Contact

Lindsay A Hampson, MD
CONTACT
415-353-2200
lindsay.hampson@ucsf.edu
Rory Grant
CONTACT
(415) 353-7615
rory.grant2@ucsf.edu

Principal Investigator

Lindsay Hampson, MD
PRINCIPAL_INVESTIGATOR
University of California, San Francisco

Study Locations (Sites)

University of California San Francisco
San Francisco, California, 94143
United States
MedStar Urology
Washington, District of Columbia, 20037
United States

Collaborators and Investigators

Sponsor: University of California, San Francisco

  • Lindsay Hampson, MD, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-02-15
Study Completion Date2026-03-01

Study Record Updates

Study Start Date2022-02-15
Study Completion Date2026-03-01

Terms related to this study

Keywords Provided by Researchers

  • buccal urethroplasty
  • urethral stricture
  • urethroplasty
  • buccal block
  • lidocaine

Additional Relevant MeSH Terms

  • Urethral Stricture, Male