Peri-operative Oral Pain Control Following Buccal Graft Urethroplasty

Description

Patients undergoing buccal urethroplasty will often have significant post-operative oral pain from the graft site. Various graft harvest techniques and methods for post-harvest hemostasis including graft site closure have been explored. Despite the frequency of this clinical scenario there is no established best practice for peri-operative pain management in this patient population. In addition to traditional post operative pain control, groups have sought various peri-operative anesthetic regimens to improve post operative pain. This has led recently to the description of various regional blocks including buccal and periorbital blocks for peri-operative local anesthetic. No study has looked at superiority of regional pain management in this patient population. This study will aim to assess three established anesthetic protocols for oral pain control in a blinded, randomized controlled trial. Hypothesis: Patients who have buccal block will have lower post op pain without any increase adverse oral outcomes.

Conditions

Urethral Stricture, Male

Study Overview

Study Details

Study overview

Patients undergoing buccal urethroplasty will often have significant post-operative oral pain from the graft site. Various graft harvest techniques and methods for post-harvest hemostasis including graft site closure have been explored. Despite the frequency of this clinical scenario there is no established best practice for peri-operative pain management in this patient population. In addition to traditional post operative pain control, groups have sought various peri-operative anesthetic regimens to improve post operative pain. This has led recently to the description of various regional blocks including buccal and periorbital blocks for peri-operative local anesthetic. No study has looked at superiority of regional pain management in this patient population. This study will aim to assess three established anesthetic protocols for oral pain control in a blinded, randomized controlled trial. Hypothesis: Patients who have buccal block will have lower post op pain without any increase adverse oral outcomes.

Peri-operative Oral Pain Control Following Buccal Graft Urethroplasty: Randomized Control Trial of Harvest Site Anesthetic

Peri-operative Oral Pain Control Following Buccal Graft Urethroplasty

Condition
Urethral Stricture, Male
Intervention / Treatment

-

Contacts and Locations

San Francisco

University of California San Francisco, San Francisco, California, United States, 94143

Washington

MedStar Urology, Washington, District of Columbia, United States, 20037

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Men, age 18 or older
  • * Undergoing anterior urethroplasty with buccal grafting
  • * Able to consent
  • * Taking chronic opiates for pain
  • * Diagnosis of chronic pain
  • * Prior buccal urethroplasty
  • * Vulnerable population (e.g. prisoner)
  • * Renal dysfunction or allergy preventing NSAID use
  • * Liver dysfunction or allergy preventing Tylenol use
  • * Medical allergy to local anesthetic
  • * Medical allergy to Peridex/Magic Mouthwash
  • * NYHA Class III/IV
  • * Hematologic condition that excludes patient from surgery
  • * Post-operative complication resulting in inpatient stay
  • * Anesthetic complication
  • * No buccal site surgical complication

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

MALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, San Francisco,

Lindsay Hampson, MD, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

2026-03-01