RECRUITING

Oxalate and Citrate

Conditions

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is a single-center study that aims to earn more about how two different compounds found in food, oxalate and citrate, may affect a person's chances of forming kidney stones.

Official Title

Oxalate and Citrate in Humans

Quick Facts

Study Start:2022-10-27

Study Completion:2025-07-01

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT05334979

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 70 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Age 18-70 * History of at least one calcium-based kidney stone * Age 18-70 * No history of kidney stone * 24-hour urine oxalate within lab normal (\<50mg/day)	* History of primarily uric acid, cysteine, or struvite stones. * History of severe acid-base abnormality, very low (less than 100mg/day) or very high (greater than 1500mg/day) urine citrate. * Any controls or stone-forming participants who cannot stop diuretic medication or alkali supplementation for the course of the study period. * Non-stone formers and stone-formers with extreme levels of urine citrate will be excluded from this small initial study to reduce heterogeneity and remove focus from the extremes of citrate levels.

Inclusion Criteria

Exclusion Criteria

* Age 18-70
* History of at least one calcium-based kidney stone
* Age 18-70
* No history of kidney stone
* 24-hour urine oxalate within lab normal (\<50mg/day)

* History of primarily uric acid, cysteine, or struvite stones.
* History of severe acid-base abnormality, very low (less than 100mg/day) or very high (greater than 1500mg/day) urine citrate.
* Any controls or stone-forming participants who cannot stop diuretic medication or alkali supplementation for the course of the study period.
* Non-stone formers and stone-formers with extreme levels of urine citrate will be excluded from this small initial study to reduce heterogeneity and remove focus from the extremes of citrate levels.

Contacts and Locations

Study Locations (Sites)

University of Chicago Medical Center

Chicago, Illinois, 60637

United States

Collaborators and Investigators

Sponsor: University of Chicago

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-10-27

Study Completion Date2025-07-01

Study Record Updates

Study Start Date2022-10-27

Study Completion Date2025-07-01

Terms related to this study

Additional Relevant MeSH Terms

Kidney Stone
Normal Controls