Oxalate and Citrate

Description

This is a single-center study that aims to earn more about how two different compounds found in food, oxalate and citrate, may affect a person's chances of forming kidney stones.

Conditions

Kidney Stone, Normal Controls

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Study Overview

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Study Details

Study overview

This is a single-center study that aims to earn more about how two different compounds found in food, oxalate and citrate, may affect a person's chances of forming kidney stones.

Oxalate and Citrate in Humans

Oxalate and Citrate

Condition
Kidney Stone
Intervention / Treatment

-

Contacts and Locations

Chicago

University of Chicago Medical Center, Chicago, Illinois, United States, 60637

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 18-70
  • * History of at least one calcium-based kidney stone
  • * Age 18-70
  • * No history of kidney stone
  • * 24-hour urine oxalate within lab normal (\<50mg/day)
  • * History of primarily uric acid, cysteine, or struvite stones.
  • * History of severe acid-base abnormality, very low (less than 100mg/day) or very high (greater than 1500mg/day) urine citrate.
  • * Any controls or stone-forming participants who cannot stop diuretic medication or alkali supplementation for the course of the study period.
  • * Non-stone formers and stone-formers with extreme levels of urine citrate will be excluded from this small initial study to reduce heterogeneity and remove focus from the extremes of citrate levels.

Ages Eligible for Study

18 Years to 70 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Chicago,

Study Record Dates

2025-07-01