RECRUITING

KM3D Multicenter Cancer Consortium: Predicting Patient Response Using 3D Cell Culture Models

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study will assess the ability of the Known Medicine platform to predict the efficacy of certain cancer drug treatments and to validate that tumor organoid drug sensitivity is representative of patient treatment outcomes.

Official Title

KM3D Multicenter Cancer Consortium Study: Validation of In Vitro 3D Cell Culture Models for Tumor Drug Sensitivity After Tissue Removal

Quick Facts

Study Start:2021-01-12
Study Completion:2026-01-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05338073

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * A demonstrated primary solid cancer for which it is medically indicated and planned to be surgically resected, biopsied, or drained (via malignant pleural effusion).
  2. * The ability to ship the tissue sample within 24 hours of removal from the patient.
  3. * Signed and dated consent to giving tissue as well as allowing for de-identified medical history information regarding administered treatments and treatment outcomes to be shared.
  4. * over 18 years of age
  1. * Presence of a condition(s) or diagnosis, either physical or psychological, or physical exam finding that precludes participation in the opinion of the Investigator.

Contacts and Locations

Study Contact

Charlotte Waits, PhD
CONTACT
801-953-0895
clinical@knownmed.com
Andrea Mazzocchi, PhD
CONTACT
andrea@knownmed.com

Principal Investigator

Andrea Mazzocchi, PhD
PRINCIPAL_INVESTIGATOR
Known Medicine, Inc.

Study Locations (Sites)

Mayo Clinic
Rochester, Minnesota, 55905
United States
Duke Cancer Institute
Durham, North Carolina, 27710
United States
MD Anderson Cancer Center
Houston, Texas, 77030
United States

Collaborators and Investigators

Sponsor: Known Medicine, Inc.

  • Andrea Mazzocchi, PhD, PRINCIPAL_INVESTIGATOR, Known Medicine, Inc.

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-01-12
Study Completion Date2026-01-31

Study Record Updates

Study Start Date2021-01-12
Study Completion Date2026-01-31

Terms related to this study

Additional Relevant MeSH Terms

  • Cancer
  • Predictive Cancer Model
  • Effects of Chemotherapy