RECRUITING

Optimizing Pulsatility During Cardiopulmonary Bypass

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Cardiopulmonary bypass during cardiac surgery provides blood flow to the body during surgery but has adverse effects on different organs. Blood flow during cardiopulmonary bypass may be pulsatile or non-pulsatile, which may impact normal organ function after surgery. The study will collect data on the type of cardiopulmonary bypass used during surgery and organ function to determine if there is an association between the type of bypass and organ function.

Official Title

Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury: Prospective Observational Study

Quick Facts

Study Start:2022-07-05
Study Completion:2025-07-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05344573

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:50 Years to 70 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age 50 to 70
  2. * Able to provide informed consent
  3. * Scheduled for elective cardiac surgery with cardiopulmonary bypass
  1. * Patients undergoing emergency procedures
  2. * Diagnosed with sepsis
  3. * Experiencing delirium
  4. * Experiencing hemodynamic instability (heart rate \> 100 and systolic blood pressure \< 90)
  5. * Patients with a mechanical circulatory support device
  6. * Requiring vasoactive medications before surgery
  7. * Patients with a reduced left ventricular ejection fraction (less than 50%)
  8. * Patients with a contraindication to transesophageal echocardiography

Contacts and Locations

Study Contact

Nathan J Clendenen, MD, MS
CONTACT
(303) 724-5375
nathan.clendenen@cuanschutz.edu

Principal Investigator

Nathan J Clendenen, MD, MS
PRINCIPAL_INVESTIGATOR
University of Colorado Denver | Anschutz

Study Locations (Sites)

University of Colorado Hospital
Aurora, Colorado, 80045
United States

Collaborators and Investigators

Sponsor: University of Colorado, Denver

  • Nathan J Clendenen, MD, MS, PRINCIPAL_INVESTIGATOR, University of Colorado Denver | Anschutz

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-07-05
Study Completion Date2025-07-01

Study Record Updates

Study Start Date2022-07-05
Study Completion Date2025-07-01

Terms related to this study

Keywords Provided by Researchers

  • Endothelial function
  • Acute Kidney Injury
  • Cardiopulmonary bypass
  • Cardiac surgery

Additional Relevant MeSH Terms

  • Endothelial Dysfunction
  • Acute Kidney Injury