Optimizing Pulsatility During Cardiopulmonary Bypass

Description

Cardiopulmonary bypass during cardiac surgery provides blood flow to the body during surgery but has adverse effects on different organs. Blood flow during cardiopulmonary bypass may be pulsatile or non-pulsatile, which may impact normal organ function after surgery. The study will collect data on the type of cardiopulmonary bypass used during surgery and organ function to determine if there is an association between the type of bypass and organ function.

Conditions

Endothelial Dysfunction, Acute Kidney Injury

Study Overview

Study Details

Study overview

Cardiopulmonary bypass during cardiac surgery provides blood flow to the body during surgery but has adverse effects on different organs. Blood flow during cardiopulmonary bypass may be pulsatile or non-pulsatile, which may impact normal organ function after surgery. The study will collect data on the type of cardiopulmonary bypass used during surgery and organ function to determine if there is an association between the type of bypass and organ function.

Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury: Prospective Observational Study

Optimizing Pulsatility During Cardiopulmonary Bypass

Condition
Endothelial Dysfunction
Intervention / Treatment

-

Contacts and Locations

Aurora

University of Colorado Hospital, Aurora, Colorado, United States, 80045

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 50 to 70
  • * Able to provide informed consent
  • * Scheduled for elective cardiac surgery with cardiopulmonary bypass
  • * Patients undergoing emergency procedures
  • * Diagnosed with sepsis
  • * Experiencing delirium
  • * Experiencing hemodynamic instability (heart rate \> 100 and systolic blood pressure \< 90)
  • * Patients with a mechanical circulatory support device
  • * Requiring vasoactive medications before surgery
  • * Patients with a reduced left ventricular ejection fraction (less than 50%)
  • * Patients with a contraindication to transesophageal echocardiography

Ages Eligible for Study

50 Years to 70 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Colorado, Denver,

Nathan J Clendenen, MD, MS, PRINCIPAL_INVESTIGATOR, University of Colorado Denver | Anschutz

Study Record Dates

2025-07-01