RECRUITING

Intrathecal Morphine for Analgesia in Video-assisted Thoracic Surgery

Description

VATS is widely used for diagnosis and treatment of intrathoracic conditions. Despite many benefits, postoperative pain continues to be intense after VATS. The optimal strategy for pain management has not been defined. In this randomized, placebo-controlled, double-blinded clinical investigation, investigators hypothesize that 5 mcg/kg intrathecal morphine will decrease postoperative analgesic consumption and reduce pain.

Conditions

Pain, Postoperative
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Related Conditions:

Pain, Postoperative

Study Overview

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Study Details

Study overview

VATS is widely used for diagnosis and treatment of intrathoracic conditions. Despite many benefits, postoperative pain continues to be intense after VATS. The optimal strategy for pain management has not been defined. In this randomized, placebo-controlled, double-blinded clinical investigation, investigators hypothesize that 5 mcg/kg intrathecal morphine will decrease postoperative analgesic consumption and reduce pain.

Intrathecal Morphine for Postoperative Analgesia in Video-Assisted Thoracic Surgery: A Randomized, Placebo-controlled, Double-blinded Clinical Trial

Intrathecal Morphine for Analgesia in Video-assisted Thoracic Surgery

Condition
Pain, Postoperative
Intervention / Treatment

-

Contacts and Locations

Chicago

University of Chicago, Chicago, Illinois, United States, 60637

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 18-80 years old
  • * Undergoing elective video-assisted thoracoscopic surgery for anatomical lung resection
  • * General anesthesia with anticipated intraoperative extubation.
  • * American Society of Anesthesiologists (ASA) classification of 4 or 5
  • * Anticipated postoperative intubation
  • * Significant liver disease
  • * Preoperative use of intravenous inotropes and/or vasopressor support
  • * Preoperative mechanical ventilation
  • * Preoperative use of mechanical circulatory support device (intraaortic balloon pump, ventricular assist device, extracorporeal membrane oxygenation)
  • * Severe pulmonary disease (home oxygen requirement and/or current oral steroid use)
  • * Morphine allergy
  • * Opioid or alcohol abuse
  • * Chronic pain
  • * Renal failure
  • * Inability to comprehend English language
  • * Bleeding disorder
  • * Abnormal preoperative coagulation
  • * Infection
  • * Patient refusal

Ages Eligible for Study

18 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Chicago,

Study Record Dates

2026-03-01