RECRUITING

Intrathecal Morphine for Analgesia in Video-assisted and Robotic-assisted Thoracic Surgery

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

VATS/RATS is widely used for diagnosis and treatment of intrathoracic conditions. Despite many benefits, postoperative pain continues to be intense after VATS/RATS. The optimal strategy for pain management has not been defined. In this randomized, placebo-controlled, double-blinded clinical investigation, investigators hypothesize that 5 mcg/kg intrathecal morphine will decrease postoperative analgesic consumption and reduce pain.

Official Title

Intrathecal Morphine for Postoperative Analgesia in Video-Assisted and Robotic-Assisted Thoracic Surgery: A Randomized, Placebo-controlled, Double-blinded Clinical Trial

Quick Facts

Study Start:2023-09-29
Study Completion:2026-09-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05351229

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age 18-80 years old
  2. * Undergoing elective video-assisted thoracoscopic or robotic assisted surgery for anatomical lung resection
  3. * General anesthesia with anticipated intraoperative extubation.
  1. * American Society of Anesthesiologists (ASA) classification of 4 or 5
  2. * Anticipated postoperative intubation
  3. * Significant liver disease
  4. * Preoperative use of intravenous inotropes and/or vasopressor support
  5. * Preoperative mechanical ventilation
  6. * Preoperative use of mechanical circulatory support device (intraaortic balloon pump, ventricular assist device, extracorporeal membrane oxygenation)
  7. * Severe pulmonary disease (home oxygen requirement and/or current oral steroid use)
  8. * Morphine allergy
  9. * Opioid or alcohol abuse
  10. * Chronic pain
  11. * Renal failure
  12. * Inability to comprehend English language
  13. * Bleeding disorder
  14. * Abnormal preoperative coagulation
  15. * Infection
  16. * Patient refusal

Contacts and Locations

Study Contact

Richa Dhawan, MD MPH
CONTACT
312-695-0061
richa.dhawan@northwestern.edu

Study Locations (Sites)

University of Chicago
Chicago, Illinois, 60637
United States

Collaborators and Investigators

Sponsor: Northwestern University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-09-29
Study Completion Date2026-09-01

Study Record Updates

Study Start Date2023-09-29
Study Completion Date2026-09-01

Terms related to this study

Additional Relevant MeSH Terms

  • Pain, Postoperative